Figure 3
From: Neuroimmune characterization of optineurin insufficiency mouse model during ageing
Similar inflammatory profiles in the brains and spinal cords of aged Optn470T and WT mice. RayBio® C-Series Mouse Inflammation Antibody Array C1 was performed on brain and spinal cord lysates from two-year-old male WT and Optn470T mice. Selected pro- and anti-inflammatory cytokines in the brain (A) and spinal cord (D) from WT and Optn470T mice are shown normalized to WT. Three independent experiments were performed from the following groups of mice: (1) 4 WT and 5 Optn470T; (2) 1 WT, 5 Optn470T; (3) 4 WT, 3 Optn470T. Brain lysates from 9 two-year-old male WT and 13 Optn470T mice were assayed by ELISA for TNF-α (B) and IFN-β (C). The data were analysed by Mann–Whitney ((A): ITAC, IL-4; (C,D): IL-4) and Student’s t-test ((A): TNF-α, CCL2, fractalkine; (B,D): XCL1, TNF-α, CCL2, fractalkine); *p < 0.05.
