Table 5 Evaluation of hematologic parameters indicating myelosuppression in patients with poor/intermediate and normal/rapid CYP2B6 function.
Poor/intermediate CYP2B6 metabolizers | Normal/rapid CYP2B6 metabolizers | P value | |
|---|---|---|---|
Lymphocytes (N = 47) | 0.015 | ||
Grade 0 | 5.6% (1/18) | 0.0% (0/29) | |
Grade 1/2 | 22.2% (4/18) | 3.4% (1/29) | |
Grade 3 | 72.2% (13/18) | 96.6% (28/29) | |
Platelets (N = 50) | 0.018 | ||
Grade 0 | 35.0% (7/20) | 10.0% (3/30) | |
Grade 1/2 | 15.0% (3/20) | 10% (3/30) | |
Grade 3/4 | 50.0% (10/20) | 80.0% (24/30) | |
Neutrophils (N = 49) | 0.306 | ||
Grade 0 | 0.0% (0/19) | 0.0% (0/30) | |
Grade 1/2 | 10.5% (2/19) | 3.3% (1/30) | |
Grade 3/4 | 89.5% (17/19) | 96.7% (29/30) | |
Monocytes (N = 45) | 0.030 | ||
> LLN* | 27.8% (5/18) | 3.7% (1/27) | |
< LLN* | 72.2% (13/18) | 96.3% (26/27) | |
Eosinophils (N = 45) | 0.449 | ||
> LLN* | 27.8% (5/18) | 14.8% (4/27) | |
< LLN* | 72.2% (13/18) | 85.2% (23/27) | |
Red blood cells (N = 50) | 0.489 | ||
> LLN* | 15.0% (3/20) | 26.7% (8/30) | |
< LLN* | 85.0% (17/20) | 73.3% (22/30) | |
