Figure 6

Structural cells are highly influential in the signaling interactions with other immune cells and non-immune cells in the liver. CellChat analyses enabled us to investigate signaling pathways based on the exact ligand and receptor pairs detected in each cell type, using the truncated mean of 2.5% analysis results. We focused on signaling coming from structural cells to immune cells, in which many functional signaling molecules were detected in endothelial cells (upper panel) and fibroblasts (lower panel) across groups.