Figure 8 | Scientific Reports

Figure 8

From: Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct

Figure 8

Acetylation activity of p300 is necessary for transcriptional changes observed upon expression of BRD4-p300(FL). (a) Percent of genes affected upon expression of different BRD4-p300 constructs. (b) Graph showing logFC for SOX2 and TP63 genes upon expression of different BRD4-p300 constructs. (c) PCA plot, summarizing RNAseq data for cells expressing all constructs. Cell lines excluded in this plot: BRD4-NUT(FL) and BRD4-NUT(MIN) are included in the full PCA in Fig. S4b. (d) Summary of molecular parts of p300 required for condensate formation, condensate-localized acetylation and transcriptional changes in cells. (e) Final model of condensate formation.

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