Figure 6 | Scientific Reports

Figure 6

From: Schwann cell-encapsulated chitosan-collagen hydrogel nerve conduit promotes peripheral nerve regeneration in rodent sciatic nerve defect models

Figure 6

Promoted axonal regrowth and remyelination by CCN with SCs. (a) Representative images of immunohistochemistry staining for anti-P0 and anti-NFH antibody, counterstained with Hoechst, at 12 weeks after transplantation. (b) Number of regenerated axons, (c) P0-positive area, (d) NFH-positive area. *P < 0.05. Quantitative analysis of the axial section immunofluorescence. The number of regenerated axons and P0-positive area in the CCN+ group is significantly larger than those in the CCN− and silicone+ groups, but there is no significant difference between the CCN− and silicone+ groups. These results indicate that SC-encapsulated CCN promotes axonal regrowth and remyelination of regenerated axons.

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