Figure 2 | Scientific Reports

Figure 2

From: Sericin coated thin polymeric films reduce keratinocyte proliferation via the mTOR pathway and epidermal inflammation through IL17 signaling in psoriasis rat model

Figure 2

Histopathological lesions and severity score in psoriasis rats with any treatment: (A) Histopathological images of epidermal thickening and epidermal length in any treatment, compared with normal skin, (B) Main histopathological changes in imiquimod-induced psoriasis; an elongation of rete ridges extended to dermis (acanthosis), a thickening of the stratum corneum (hyperkeratosis), a deposition of exudate including tissue debris and inflammatory cells, particularly neutrophil (pustule), an increase in the size of epidermal cell (edema), a formation of cysts in the dermis, with a perforating epidermal component (squamous cyst), an infiltration of inflammatory cells in the dermis (dermatitis) or the hair follicle (folliculitis), (C) A bar graph of epidermal histopathological score in various skin conditions such as acanthosis, hyperkeratosis, pustule, epidermal edema and swelling, squamous cyst, dermatitis, and folliculitis in comparison with normal skin.

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