Table 3 Association between age at gonad removal and risk for any cranial cruciate ligament (CCL) rupture: An analysis of three distinct windows of gonad exposure (≤ 6 months, 6.01–12 months, 12.01–24 months) during the developmental period.

From: Correlates of estimated lifetime cruciate ligament survival inform potential rupture risk reduction strategies: findings from the Exceptional Aging in Rottweilers Study

 

Gonad exposure

Hazard ratio

95% CI

p-value

 

 > 24 months (n = 90)

1.0 (ref)

–

–

Windows During Developmental Period

12.01–24 months (n = 12)

3.43

1.45–8.10

0.005

3.40*

1.42–8.15

0.006

6.01–12 months (n = 10)

3.17

1.19–8.44

0.02

2.95*

1.08–8.09

0.04

 < 6 months (n = 11)

10.34

4.59–23.31

< 0.001

8.33*

3.49–19.88

< 0.001

  1. For each developmental window, hazard ratio (HR) and 95% confidence interval (95% CI) for CCL rupture were generated using Cox proportional hazards modeling using dogs with > 24 months gonad exposure as reference (ref) group (HR = 1.0). n = 123.
  2. *Represents the adjusted hazard ratio (HR) including sex, adult height, and body condition in multivariate analysis.
Back to article page