Figure 3
Circadian rhythm protein–protein interactome network. Network made up of 13 CCCs (sky blue nodes; mean degree centrality = 17.2), 37 (29%) CCPs (red nodes; mean degree centrality = 16.6), and 76 (37%) proteins involved in the NMCRE (green nodes; mean degree centrality = 18.0) with at least one high-confidence interaction (cutoff > 0.9) with cancer driver proteins (pink node; mean degree centrality = 19.4). The Mann–Whitney U test showed a correlation of degree centrality between cancer driver nodes and CR-related nodes (P > 0.05). The CR-related proteins with both the highest degree centrality and the CR-cancer scores > 0.9 were EP300, TP53, HDAC1, MAPK8, and BTRC. Lastly, the CR-PPi network was designed and visualized through the Cytoscape software v.3.10 (https://cytoscape.org/)72. CR circadian rhythm, PPi protein–protein interaction, CCCs canonical clock components, CCPs clock-controlled proteins, NMCRE neural mechanisms of circadian rhythmicity and its entrainment.
