Figure 6
Pharmacogenomic clinical annotations and clinical trials. (A) Identification of known and predicted oncogenic variants (n = 765) through the boostDM machine learning-based method49. (B) Sankey plot of in silico drug prescription based on pharmacogenomic clinical annotations. (C) Overview of phase III and IV clinical trials. Sankey plot showing therapeutic targets, drugs, mechanisms of action, and cancer types involved in late phase clinical trials. Data of clinical trials and mechanisms of action were taken from the Open Targets Platform (https://platform.opentargets.org/)29, and the Drug Repurposing Hub (https://clue.io/repurposing)89. Lastly, Sankey plots were designed using the SankeyMATIC software (https://sankeymatic.com/ and https://github.com/nowthis/sankeymatic) CR circadian rhythm.
