Table 3 Multivariable Cox regression analysis of IL-1B and IL-8 polymorphisms disease-free and overall survival in iCCA.

From: Genetic polymorphisms in interleukin-1β (rs1143634) and interleukin-8 (rs4073) are associated with survival after resection of intrahepatic cholangiocarcinoma

 

Disease-free survival (DFS)

Overall survival (OS)

Hazard ratio (95% CI)§

p

Hazard ratio (95% CI)#

p

IL-1B +3954 C > T (rs1143634)

 

.526

 

.013

 C/T or T/T (favorable)

1

 

1

 

 C/C (unfavorable)

1.233 (.645–2.360)

 

2.444 (1.204–4.962)

 

IL-8 -251 T > A (rs4073)

 

n.a.&

 

.026

 T/T (favorable)

n.a.&

 

1

 

 T/A (unfavorable)

n.a.&

 

2.318 (1.158–4.640)

 

 A/A (unfavorable)

n.a.&

 

1.967 (.363–2.577)

 

Combined

 

n.a.&

  

 0 unfavorable

n.a.&

 

1

.007

 1 unfavorable

n.a.&

 

0.880 (0.268–2.895)

 

 2 unfavorable

n.a.&

 

2.395 (0.747–7.895)

 
  1. Based on Cox proportional hazards model, for DFS including: blood transfusions, microvascular invasion, lymphovascular invasion, lymph node positivity, UICC stage. For OS including: alkaline phosphatase, hemoglobin, C-reactive protein, blood transfusions, microvascular invasion, lymphovascular invasion, lymph node positivity, UICC stage, comprehensive complication index and hospitalization. Also see Supplementary Table 2 and 3.
  2. CI confidence interval, iCCA intrahepatic cholangiocarcinoma, IL interleukin.
  3. §83 patients with complete data were included in the model.
  4. #84 patients with complete data were included in the model.
  5. &Not significant in univariable analysis (log-rank test), therefore variable was not included in multivariable analysis.
  6. Significant values are in bold.
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