Table 2 Calculated logP values and in vitro biological effects of the hit compounds.
From: In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues
Compound | clogP | IC50 (µM) against Pf3D7 | IC50 (µM) against PfRKL-9 | Cella survival (%) at 500 µM |
|---|---|---|---|---|
| 3.7706 | 1.31 ± 1.1 | 1.83 ± 0.7 | 45% |
| 5.6566 | 0.92 ± 1.8 | 2.1 ± 1.3 | 55% |
| 5.1384 | 1.78 ± 1.3 | 9.55 ± 1.7 | 52% |
| 4.9244 | 1.33 ± 1.07 | 1.84 ± 1.06 | 51% |
| 5.0137 | 1.15 ± 1.5 | 2.21 ± 1.3 | 60% |
| 5.0603 | 0.025 (25 nM) | 0.125 (125 nM) | – |
