Table 1 Baseline characteristics in Alzheimer´s disease and vascular dementia patients and controls.

From: Analysis of endothelial gene polymorphisms in Spanish patients with vascular dementia and Alzheimer´s disease

Characteristics

Control N = 150

AD N = 147

Pa

VaD Total sample N = 150

Pb

Large-vessel VaD n = 74

Pc

Small-vessel VaD n = 76)

Pd

Age, years, mean (SD)

81.2 (5)

79.8 (6.9)

0.276

78.6 (7.2)

0.000

78.2 (7.6)

0.001

78.9 (6.7)

0.004

Sex, n(% women)

74 (49.3)

93 (63.3)

0.016

74 (49.3)

1.000

31 (41.9)

0.294

43 (56.6)

0.303

Education, n(%)

 ≤ 8 years

21 (14)

31 (21.1)

0.083

43 (28.7)

0.013

18 (24.3)

0.134

25 (32.9)

0.005

 8–13 years

52 (34.7)

59 (40.1)

 

36 (24)

 

19 (25.7)

 

17 (22.4)

 

Elementary

65 (43.3)

52 (35.4)

 

59 (39.3)

 

28 (37.8)

 

31 (40.8)

 

High school/college

12 (8)

4 (3.4)

 

12 (8)

 

9 (12.2)

 

3 (3.9)

 

Hypertension, n(%)

107 (71.3)

67 (45.6)

0.000

127 (84.7)

0.005

61 (82.4)

0.071

66 (86.8)

0.009

Diabetes mellitus, n(%)

36 (24)

17 (11.6)

0.005

55 (36.7)

0.017

27 (36.5)

0.051

28 (36.8)

0.043

Hypercholesterolemia, n(%)

58 (38.7)

55 (37.4)

0.824

85 (56.7)

0.002

35 (47.3)

0.218

50 (65.8)

0.000

Alcohol, n(%)

6 (4)

11 (7.5)

0.196

26 (17.3)

0.000

14 (18.9)

0.000

12 (15.8)

0.002

Smoking, n(%)

37 (24.7)

24 (16.3)

0.075

52 (34.7)

0.058

27 (36.5)

0.066

25 (32.9)

0.190

  1. Statistically significant results between patients with AD or VaD and control participants, using the Chi-square test for categorical data and the unpaired t-test for the continuous data, are indicated in bold. Abbreviations: AD, Alzheimer´s disease; SD, standard deviation; VaD, vascular dementia. Pa denotes P < 0.05 among controls and patients with AD; Pb denotes P < 0.05 among controls and patients with VaD; Pc denotes P < 0.05 among controls and large-vessel VaD; and Pd denotes P < 0.05 among controls and small-vessel VaD.