Table 3 VEGFR2 gene polymorphism and large-vessel and small-vessel vascular dementia subgroups: association statistics.

From: Analysis of endothelial gene polymorphisms in Spanish patients with vascular dementia and Alzheimer´s disease

SNP

Large-vessel VaD

Small-vessel VaD

Case n = 74

OR (95%CI)

P

aOR (95%CI)

Pa

Case n = 76

OR (95%CI)

P

aOR (95%CI)

Pa

VEGFR2 rs2071559

 AA

24 (32.4)

1.00 (Ref.)

 

1.00 (Ref.)

 

13 (17.1)

1.00 (Ref.)

 

1.00 (Ref.)

 

 AG

31 (41.9)

0.67 (0.34–1.33)

0.260

0.73 (0.35–1.48)

0.379

32 (42.1)

1.14 (0.53–2.43)

0.744

1.11 (0.48–2.54)

0.808

 GG

19 (25.7)

1.06 (0.48–2.35)

0.889

0.99 (0.42–2.31)

0.975

31 (40.8)

2.91 (1.28–6.63)

0.011

2.59 (1.06–6.35)

0.038

 Dominant

 

0.78 (0.41–1.47)

0.447

0.79 (0.41–1.56)

0.502

 

1.61 (0.79–3.28)

0.193

1.53 (0.70–3.34)

0.284

 Recessive

 

0.74 (0.37–1.46)

0.384

0.83 (0.40–1.70)

0.611

 

0.37 (0.20–0.70)

0.002

0.41 (0.21–0.82)

0.011

  1. OR (95%CI) and P values obtained with multivariate unconditional logistic regression analysis by adjusting for age and gender as covariates. aORs (95%CI) and Pa values adds education, hypertension, type 2 diabetes mellitus, hypercholesterolemia, smoking and alcohol consumption as covariates. Significant P values (< 0.05) are displayed in bold.
  2. aOR,adjusted odds ratio, CI confidence interval, OR odds ratio, ref reference, SNP single nucleotide polymorphism, VaD vascular dementia.
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