Table 4 VEGF gene polymorphism and Alzheimer´s disease by APOE ε4 status: association statistics.

From: Analysis of endothelial gene polymorphisms in Spanish patients with vascular dementia and Alzheimer´s disease

VEGF rs699947

Controls N = 150

Alzheimer Disease

Characters

Cases N = 147

aOR (95% CI)1

P value1

aOR (95% CI)2

P value2

APOE ε4( +)

n = 17

n = 60

    

 CC

3 (17.6)

18 (30.0)

1.00 (Reference)

 

1.00 (Reference)

 

 CA

11 (64.8)

27 (45.0)

0.21 (0.04–1.02)

0.053

0.13 (0.02–0.78)

0.026

 AA

3 (17.6)

15 (25.0)

0.31 (0.04–2.26)

0.247

0.19 (0.02–1.68)

0.135

 Dominant

  

0.23 (0.05–1.05)

0.059

0.14 (0.02–0.79)

0.026

 Recessive

  

1.18 (0.23–5.95)

0.845

1.43 (0.25–8.09)

0.688

APOE ε4(-)

n = 133

n = 87

    

 CC

37 (27.8)

32 (36.8)

1.00 (Reference)

 

1.00 (Reference)

 

 CA

58 (43.6)

42 (48.3)

0.75 (0.39–1.42)

0.374

0.73 (0.37–1.45)

0.372

 AA

38 (28.6)

13 (14.9)

0.38 (0.17–0.86)

0.021

0.36 (0.15–0.85)

0.019

 Dominant

  

0.61 (0.33–1.11)

0.104

0.59 (0.31–1.11)

0.100

 Recessive

  

2.17 (1.06–4.42)

0.033

2.25 (1.07–4.77)

0.033

  1. 1Adjusted ORs (95%CI) and P values obtained with multivariate unconditional logistic regression analysis by adjusting for age and gender as covariates. 2Adjusted ORs (95%CI) and P values of all models on the basis of risk factors such as age, gender, education, hypertension, type 2 diabetes mellitus, hypercholesterolemia, smoking and alcohol consumption. Significant P values (< 0.05) are displayed in bold.
  2. aOR adjusted odds ratio, CI confidence interval.
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