Table 5 Logistic regression analysis showing independent variables associated with rapid progression of Alzheimer´s disease.

From: Analysis of endothelial gene polymorphisms in Spanish patients with vascular dementia and Alzheimer´s disease

Variable

Rapid progressors

OR

95% CI

P value

Age at diagnosis

0.93

0.86–1.02

0.130

Sex

0.36

0.11–1.25

0.107

Education

0.65

0.31–1.33

0.240

hypertension

0.24

0.06–0.99

0.049

type 2 DM

1.61

0.20–12.83

0.652

hypercholesterolemia

0.98

0.23–4.14

0.978

smoking

0.27

0.04–1.75

0.169

alcohol

1.09

0.10–11.48

0.942

Depression

1.29

0.41–4.02

0.665

Psychosis

5.50

1.44–20.98

0.013

AChEI/memantine

0.82

0.45–1.47

0.502

Follow-up time

0.44

0.29–0.65

0.0001

APOE ε4 carriers

1.24

0.36–4.26

0.733

VEGFA TT vs TC-CC

1.77

0.52–6.07

0.364

VEGFR2 AA vs AG-GG

2.98

0.86–10.37

0.086

NOS3 GG vs GT-TT

0.22

0.05–0.99

0.048

  1. OR and their 95% CI were calculated to demonstrate the independent association between good prognosis and eNOS GG genotype. Significant P values (< 0.05) are displayed in bold.
  2. AChEI cholinesterase inhibitor, CI confidence interval, OR odds ratio.
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