Table 2 Relationship between TL and parameters at the baseline.

Parameters	Linear regression analysis				Binary logistic regression analysis in regard to the cut-off index of TL
	Univariate model		Multivariate model
	Coefficients (95% CI)	p-value	Coefficients (95% CI)	p-value	Odds ratio
Age	0.037 (− 0.053 to 0.120)	0.45
ACPA	0.000 (− 0.002 to 0.003)	0.80
RF	0.001 (− 0.004 to 0.006)	0.61
Disease duration	0.181 (0.026 to 0.336)	< 0.05	0.068 (− 0.229 to 0.365)	0.65	0.967
TJC	0.190 (− 0.218 to 0.598)	0.35
SJC	− 0.007 (− 0.265 to 0.251)	0.96
PGA	0.397 (− 0.041 to 0.835)	0.076
EGA	0.308 (− 0.288 to 0.903)	0.31
CRP	− 0.079 (− 0.531 to 0.372)	0.73
DAS28	0.567 (− 0.475 to 1.609)	0.29
CDAI	0.054 (− 0.062 to 0.171)	0.36
SDAI	0.032 (− 0.068 to 0.133)	0.53
HAQ-DI	2.696 (0.596 to 4.796)	< 0.05	− 2.208 (− 5.504 to 1.351)	0.23	0.999
PS-VAS	0.064 (0.023 to 0.104)	< 0.01	0.097 (0.034 to 0.159)	< 0.01	0.988
SHS	0.052 (0.031 to 0.072)	< 0.001	0.060 (0.030 to 0.091)	< 0.001	0.994
QOLS	− 19.792 (− 31.55 to − 8.03)	< 0.01	− 25.994 (− 42.049 to − 9.938)	< 0.001	24.789

TL time length from the baseline to the first Boolean remission, ACPA anti-cyclic citrullinated polypeptide antibodies, RF rheumatoid factor, TJC tenderness joint count, SJC swollen joint count, PGA patient's global assessment, EGA evaluator's global assessment, CRP C-reactive protein, DAS28 28-joints disease activity score, CDAI clinical disease activity index, SDAI simplified disease activity index, HAQ-DI Health Assessment Questionnaire Disability Index, PS-VAS pain score using visual analog scale, SHS Sharp/van der Heijde Score, QOLS quality of life score.
Statistical analyses were performed using univariate linear regression analysis as the time span was defined as dependent factor and the parameters were defined as independent factors, and then multivariate linear regression analysis was performed with the parameters that demonstrated significant correlation with the univariate model.
Statistically significant columns are shown in bold style.

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