Figure 3 | Scientific Reports

Figure 3

From: Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens

Figure 3

10th, 50th, and 90th percentile of the small intestine luminal colistin content along time, using a simple 1-compartment (physiologically naïve) model (simulation of 500 individuals), for dosage regimens of 75,000, 100,000, and 150,000 IU/kg/day in drinking water, 75,000 IU/kg oral gavage and 75,000 IU/kg/day as 6 h-pulse dose in water. Black horizontal lines represent ECOFF, MIC for E. coli N100 (mcr-negative) and E. coli 120h_B3_5 (mcr-positive) measured in CAMHB.

Back to article page