Table 1 Pharmacokinetic parameter estimates (typical values) for the 1-compartment colistin intestinal PK model.

From: Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens

Parameter

Estimate (between subject variability %)

Units

CV%

2.5% CI

97.5% CI

Primary parameters

 ka

0.221

h−1

21.3

0.13

0.32

 V

5.14

g intestinal content/kg BW

74.4

− 2.4

12.7

 Cl

29.1 (40.5%)

g intestinal content/kg BW/h

6.3

25.5 (27%)

32.7 (51.2%)

 Multiplicative residual error

36.2

%

6.9

31.2

41.2

Secondary parameters

 ka HL

3.14

h

21.3

1.80

4.45

 Overall MTT in digestive tract

4.5

h

–

  1. Entry rate constant (ka), volume of distribution (V), clearance (Cl), half-life (HL), and Mean Transit Time (MTT), which is the average time a colistin molecule takes to transit between the crop and the jejunum. CV% and confidence interval (CI) giving precision of estimate.
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