Table 2 Model-estimated median daily colistin transit (as calculated from the median colistin concentration and clearance, Eq. (1) compared to the daily dose actually administered (back-calculated from water consumption on the day).

From: Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens

Targeted colistin dose (IU/kg BW/day)

Amount of colistin sulphate transit through the small intestine (mg/kg BW/day)

Amount of colistin base transit through the small intestine (IU/kg BW/day)

Mean daily dose of colistin administered (IU/kg BW/day)

Difference (%) between real and nominal dose

75,000

2.35

70,534

78,023

− 9.60

100,000

3.05

91,627

97,667

− 6.18

150,000

4.66

139,935

141,133

− 0.85

Back to article page