Figure 3 | Scientific Reports

Figure 3

From: Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism

Figure 3The alternative text for this image may have been generated using AI.

Plasma CYP associations with CSF proteome. Plasma CYP LA metabolite—9(10)-EpOME and CSF proteins collapsed into three cluster components (Table S5): Cluster 1—containing mostly vascular proteins, with F2, AMBP and VTN as most representative members with R2 > 0.7; Cluster 2—containing proteins involved in energy metabolism and cell proliferation, with PKM, ALDOA and PEBP1 as most representative members with R2 > 0.7; Cluster 3 containing glycolytic enzyme PGK1 and cell proliferation regulating SMOC1 and PPIA. Spearman’s rank order correlation statistics, including Spearman’s ρ and p-value are indicated for each correlation. Analysis was performed separately for AD cases and healthy controls due to significant difference in observed associations. N for AD cases = 60; healthy controls = 142.

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