Figure 4 | Scientific Reports

Figure 4

From: Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism

Figure 4The alternative text for this image may have been generated using AI.

Cerebral gene co-expression network for AD-affected proteins and genes involved in oxylipins and lipids metabolism and inflammation. Nodes are colored according to gene annotation, analogical to Figure S2-S5. White nodes represent genes involved in: oxylipins metabolism like main isoform of cytochrome P450 epoxygenase (CYP2J2), soluble epoxide hydrolase (EPHX2) microsomal epoxide hydrolase (EPHX1); lipid metabolism including fatty acids desaturase 2 (FADS2), apolipoprotein E (ApoE), hormone sensitive lipase (LIPE); inflammation—TNF Receptor Associated Factor 4 (TRAF4).

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