Figure 3
From: Disease-associated astrocytes and microglia markers are upregulated in mice fed high fat diet
Hierarchical clustering heatmaps, correlation heatmaps and theoretical regulation of gene expression in the preoptic region. (A, B) Heatmaps showing the expression profile of 15 DEGs identified from HFD cohort in dorsal preoptic region (A) and ventral preoptic region (B) overlapping with DAA, DAM and HAM markers. The left 3 columns represent 3 control samples and the rest columns on the right are samples from HFD. (C) A heatmap for 11 common DEGs found among DAA, DAM and HAM markers, HFD and AD brain samples. The red and the blue color represent up-regulated or down-regulated genes respectively. The color scales in heatmaps (A) (B) (C) represent normalized expression levels with performing pheatmap. (D) Correlation heatmap using Pearson method between DEGs and the clinical phenotypes with Pearson’s correlation coefficient in each cell between DEGs and AD clinical phenotypes. The color scale displays Pearson correlation. Red color indicates positive correlation while blue color shows negative correlation. The darker the color means the stronger correlation. (E) The plots illustrate the theoretical changes in genes from consumption of high-fat diet to the development of AD.
