Figure 1

Identification of metabolic pathways associated with moderate-severe SDB. (A): Scatter plot based on T scores from the orthogonal partial least squares discriminant analysis. Red dots and green dots indicate participants in the normal-group and moderate-severe group, respectively. (B): Volcano plot based on fold-changes in normalized peak-intensity of each metabolite for the moderate-severe SDB group compared with the normal-group and its false discovery rate-adjusted P-value. Red dots indicate the metabolites with false discovery rate-adjusted P-values < 0.05 and ranked in the top 30 according to fold changes. (C): Pathways associated with the SDB-related metabolites shown in Table S3 in the online supplement. The circle indicates pathways which include fructose. SDB sleep disordered breathing.