Table 1 Background data on study participants from the Nagahama Study.

From: Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study

 

Normal

Mild

Moderate-Severe

P-value

Number

2518

3051

804

 

Male sex, n

369 (14.7)

1173 (38.4)

488 (60.7)

 < 0.001

Age, years

52.00 [42.00, 64.00]

65.00 [54.00, 71.00]

69.00 [63.00, 74.00]

 < 0.001

Acti-ODI3%, events/hour

3.26 [2.44, 4.12]

8.05 [6.27, 10.44]

20.62 [17.25, 26.56]

 < 0.001

BMI, kg/m2

20.60 [19.10, 22.40]

22.40 [20.50, 24.40]

24.50 [22.40, 26.83]

 < 0.001

Time after the last meal, hour

14.00 [11.12, 15.00]

14.00 [11.00, 15.00]

14.00 [10.00, 15.00]

0.219

Current smoker

241 (9.6)

280 (9.2)

73 (9.1)

0.854

Never smoker

1932 (76.7)

2048 (67.1)

422 (52.5)

 < 0.001

Diabetes, n

56 (2.2)

240 (7.9)

127 (15.8)

 < 0.001

Hypertension, n

511 (20.3)

1339 (43.9)

558 (69.4)

 < 0.001

Dyslipidemia

896 (35.6)

1519 (49.8)

465 (57.8)

 < 0.001

Gout, n

15 (0.6)

119 (3.9)

53 (6.6)

 < 0.001

Systolic BP, mmHg *

118.00 [109.00, 128.00]

126.00 [116.00, 137.00]

133.00 [124.00, 143.00]

 < 0.001

Diastolic BP, mmHg *

76.00 [69.00, 83.00]

81.00 [75.00, 88.00]

85.00 [79.00, 92.00]

 < 0.001

Total protein, g/dl

7.20 [6.90, 7.50]

7.20 [7.00, 7.50]

7.30 [7.00, 7.60]

 < 0.001

Albumin, g/dl

4.30 [4.20, 4.40]

4.30 [4.10, 4.40]

4.30 [4.10, 4.40]

 < 0.001

HDL-Cholesterol, mg/dl

71.00 [60.00, 82.00]

63.00 [53.00, 75.00]

58.00 [49.00, 70.00]

 < 0.001

LDL-Cholesterol, mg/dl

114.00 [95.00, 134.00]

118.00 [99.00, 136.00]

114.00 [99.00, 135.00]

 < 0.001

Triglycerides, mg/dl

68.00 [50.00, 95.00]

85.00 [63.00, 118.00]

97.00 [69.00, 138.00]

 < 0.001

Aspartate aminotransferase, U/l

20.00 [17.00, 24.00]

22.00 [19.00, 26.00]

23.00 [20.00, 28.25]

 < 0.001

Alanine aminotransferase, U/l

15.00 [12.00, 20.00]

18.00 [14.00, 24.00]

20.00 [15.00, 29.00]

 < 0.001

γ-glutamyl transpeptidase, U/l

17.00 [13.00, 24.00]

21.00 [15.00, 33.00]

27.00 [19.00, 45.00]

 < 0.001

Alkaline phosphatase, U/l

189.00 [153.00, 233.00]

208.00 [172.00, 251.00]

217.00 [181.00, 258.25]

 < 0.001

  1. Fisher’s exact test was used for the analysis of categorical data, and Mann–Whitney’s U-test was used for continuous data.
  2. Data are noted as number (%) or median [lower, higher interquartile range] * Blood pressure data was not available for two participants.
  3. Acti-ODI3%: actigraph-adjusted oxygen desaturation index for ≥ 3% desaturation, BMI body mass index, BP blood pressure.
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