Figure 4

KEGG pathway enrichment analysis. (a) The top-10 pathways enriched among the proteins that differ in abundance between pandas with cataracts (band A) and those without cataracts (bands B + C). The enriched pathways are arranged left to right by p-value (more significant on the left) which is also represented by the logarithmic scale of the y-axis. The dotted lines represent cut-offs at significance values of p < 0.05 and p < 0.01. (b) Significant enrichment functional scatter plot in which the y-axis represents functional annotation, and the x-axis represents the Rich factor of that function (the number of differential genes enriched in a pathway divided by the total number of genes annotated in that pathway). The p-value is represented by the color of the dots, and the number of differentially expressed genes representing each function is shown by the size of the dots. Only the 14 highest enrichments are shown.