Table 3 Partial list of differentially expressed proteins (cut-off at |log2 fold change| > 1).

From: Comparative proteomics in captive giant pandas to identify proteins involved in age-related cataract formation

No.

ID

Uniprot

Genename

Log2FoldChange

Biological process

Cell component

Molecular function

KEGG pathways

UNIPROT_URL

Transcription factor

1

G1LNL2

G1LNL2

ENSAMEG00000008217

1.660934345

 

GO:0044425, membrane part|GO:0016021, integral component of membrane|GO:0016020, membrane|GO:0031224, intrinsic component of membrane

  

http://www.uniprot.org/uniprot/G1LNL2

FALSE

2

G1LPA5

G1LPA5

ENSAMEG00000008427

1.458651392

    

http://www.uniprot.org/uniprot/G1LPA5

FALSE

3

G1LUD1

G1LUD1

ENSAMEG00000010166

1.227872351

    

http://www.uniprot.org/uniprot/G1LUD1

FALSE

4

G1MB17

G1MB17

APCS

− 1.112413519

GO:0080090, regulation of primary metabolic process|GO:0019222, regulation of metabolic process|GO:0030224, monocyte differentiation|GO:0052203, modulation of catalytic activity in other organism involved in symbiotic interaction|GO:0051701, interaction with host|GO:0052205, modulation of molecular function in other organism involved in symbiotic interaction|GO:0052204, negative regulation of molecular function in other organism involved in symbiotic interaction|GO:0010605, negative regulation of macromolecule metabolic process|GO:0071704, organic substance metabolic process|GO:0048869, cellular developmental process|GO:0044419, interspecies interaction between organisms|GO:0048513, animal organ development|GO:0051817, modification of morphology or physiology of other organism involved in symbiotic interaction|GO:0044092, negative regulation of molecular function|GO:0044793, negative regulation by host of viral process|GO:1903016, negative regulation of exo-alpha-sialidase activity|GO:1903015, regulation of exo-alpha-sialidase activity|GO:0052405, negative regulation by host of symbiont molecular function|GO:1903018, regulation of glycoprotein metabolic process|GO:1903019, negative regulation of glycoprotein metabolic process|GO:0044868, modulation by host of viral molecular function|GO:0044869, negative regulation by host of viral exo-alpha-sialidase activity|GO:0051702, interaction with symbiont|GO:0044866, modulation by host of viral exo-alpha-sialidase activity|GO:0044867, modulation by host of viral catalytic activity|GO:1903706, regulation of hemopoiesis|GO:1903707, negative regulation of hemopoiesis|GO:0051704, multi-organism process|GO:0044359, modulation of molecular function in other organism|GO:0044707, single-multicellular organism process|GO:0019538, protein metabolic process|GO:0045655, regulation of monocyte differentiation|GO:0045656, negative regulation of monocyte differentiation|GO:0002376, immune system process|GO:0044788, modulation by host of viral process|GO:0046718, viral entry into host cell|GO:0009892, negative regulation of metabolic process|GO:0044871, negative regulation by host of viral glycoprotein metabolic process|GO:0044870, modulation by host of viral glycoprotein metabolic process|GO:0050789, regulation of biological process|GO:0002761, regulation of myeloid leukocyte differentiation|GO:0002762, negative regulation of myeloid leukocyte differentiation|GO:0051346, negative regulation of hydrolase activity|GO:0044260, cellular macromolecule metabolic process|GO:0002682, regulation of immune system process|GO:0002683, negative regulation of immune system process|GO:0065009, regulation of molecular function|GO:0065008, regulation of biological quality|GO:0052422, modulation by host of symbiont catalytic activity|GO:0050793, regulation of developmental process|GO:0050792, regulation of viral process|GO:0050790, regulation of catalytic activity|GO:0052428, modification by host of symbiont molecular function|GO:0006952, defense response|GO:0043903, regulation of symbiosis, encompassing mutualism through parasitism|GO:0043900, regulation of multi-organism process|GO:0043901, negative regulation of multi-organism process|GO:0051239, regulation of multicellular organismal process|GO:0030097, hemopoiesis|GO:0050794, regulation of cellular process|GO:0002521, leukocyte differentiation|GO:0002520, immune system development|GO:0051336, regulation of hydrolase activity|GO:0050896, response to stimulus|GO:0006950, response to stress|GO:0045638, negative regulation of myeloid cell differentiation|GO:0045637, regulation of myeloid cell differentiation|GO:0008152, metabolic process|GO:0030154, cell differentiation|GO:0030260, entry into host cell|GO:0052126, movement in host environment|GO:0043086, negative regulation of catalytic activity|GO:0044699, single-organism process|GO:0044362, negative regulation of molecular function in other organism|GO:0051248, negative regulation of protein metabolic process|GO:0052055, modulation by symbiont of host molecular function|GO:1903900, regulation of viral life cycle|GO:1903901, negative regulation of viral life cycle|GO:0051241, negative regulation of multicellular organismal process|GO:0051246, regulation of protein metabolic process|GO:0051851, modification by host of symbiont morphology or physiology|GO:0019058, viral life cycle|GO:0032502, developmental process|GO:0032501, multicellular organismal process|GO:0009987, cellular process|GO:0045596, negative regulation of cell differentiation|GO:0045595, regulation of cell differentiation|GO:0006955, immune response|GO:0048519, negative regulation of biological process|GO:0051093, negative regulation of developmental process|GO:1901135, carbohydrate derivative metabolic process|GO:0043170, macromolecule metabolic process|GO:0051828, entry into other organism involved in symbiotic interaction|GO:0030099, myeloid cell differentiation|GO:0048731, system development|GO:0048856, anatomical structure development|GO:0031324, negative regulation of cellular metabolic process|GO:0031323, regulation of cellular metabolic process|GO:0046596, regulation of viral entry into host cell|GO:0046597, negative regulation of viral entry into host cell|GO:0009100, glycoprotein metabolic process|GO:0007275, multicellular organism development|GO:0002573, myeloid leukocyte differentiation|GO:0060255, regulation of macromolecule metabolic process|GO:0048534, hematopoietic or lymphoid organ development|GO:0045087, innate immune response|GO:0044767, single-organism developmental process|GO:0044764, multi-organism cellular process|GO:0044763, single-organism cellular process|GO:0052403, negative regulation by host of symbiont catalytic activity|GO:0044003, modification by symbiont of host morphology or physiology|GO:0040011, locomotion|GO:0044238, primary metabolic process|GO:0040013, negative regulation of locomotion|GO:0040012, regulation of locomotion|GO:0052199, negative regulation of catalytic activity in other organism involved in symbiotic interaction|GO:0065007, biological regulation|GO:0052192, movement in environment of other organism involved in symbiotic interaction|GO:0044237, cellular metabolic process|GO:1902106, negative regulation of leukocyte differentiation|GO:1902105, regulation of leukocyte differentiation|GO:0044409, entry into host|GO:2000026, regulation of multicellular organismal development|GO:0016032, viral process|GO:0048525, negative regulation of viral process|GO:0044403, symbiosis, encompassing mutualism through parasitism|GO:0051806, entry into cell of other organism involved in symbiotic interaction|GO:0035821, modification of morphology or physiology of other organism|GO:0048523, negative regulation of cellular process|GO:1901564, organonitrogen compound metabolic process|GO:1903131, mononuclear cell differentiation|GO:0006807, nitrogen compound metabolic process

GO:0043231, intracellular membrane-bounded organelle|GO:0005622, intracellular|GO:0043230, extracellular organelle|GO:0070062, extracellular exosome|GO:0044421, extracellular region part|GO:0043227, membrane-bounded organelle|GO:0005634, nucleus|GO:0044464, cell part|GO:0005623, cell|GO:0031988, membrane-bounded vesicle|GO:0031012, extracellular matrix|GO:0043229, intracellular organelle|GO:0005576, extracellular region|GO:0005615, extracellular space|GO:0072562, blood microparticle|GO:0044424, intracellular part|GO:1903561, extracellular vesicle|GO:0065010, extracellular membrane-bounded organelle|GO:0043226, organelle|GO:0031982, vesicle

GO:0005488, binding|GO:0043169, cation binding|GO:0001849, complement component C1q binding|GO:0043167, ion binding|GO:0046790, virion binding|GO:0001848, complement binding|GO:0005509, calcium ion binding|GO:0005515, protein binding|GO:0046872, metal ion binding|GO:0001846, opsonin binding

 

http://www.uniprot.org/uniprot/G1MB17

FALSE

5

G1MJI0

G1MJI0

FGA

1.400881793

GO:2001234, negative regulation of apoptotic signaling pathway|GO:0034116, positive regulation of heterotypic cell-cell adhesion|GO:2001236, regulation of extrinsic apoptotic signaling pathway|GO:2001237, negative regulation of extrinsic apoptotic signaling pathway|GO:0019220, regulation of phosphate metabolic process|GO:0080090, regulation of primary metabolic process|GO:0019222, regulation of metabolic process|GO:2001233, regulation of apoptotic signaling pathway|GO:0051049, regulation of transport|GO:0048585, negative regulation of response to stimulus|GO:0048584, positive regulation of response to stimulus|GO:0048583, regulation of response to stimulus|GO:0019229, regulation of vasoconstriction|GO:0007160, cell-matrix adhesion|GO:0045907, positive regulation of vasoconstriction|GO:0007165, signal transduction|GO:0007166, cell surface receptor signaling pathway|GO:0003018, vascular process in circulatory system|GO:0034113, heterotypic cell-cell adhesion|GO:0023014, signal transduction by protein phosphorylation|GO:0044710, single-organism metabolic process|GO:0010604, positive regulation of macromolecule metabolic process|GO:0009968, negative regulation of signal transduction|GO:0045785, positive regulation of cell adhesion|GO:0009966, regulation of signal transduction|GO:0009967, positive regulation of signal transduction|GO:0051047, positive regulation of secretion|GO:0000165, MAPK cascade|GO:0009611, response to wounding|GO:0046879, hormone secretion|GO:0019731, antibacterial humoral response|GO:0048518, positive regulation of biological process|GO:0048519, negative regulation of biological process|GO:0033036, macromolecule localization|GO:0007599, hemostasis|GO:0031589, cell-substrate adhesion|GO:0007596, blood coagulation|GO:0051050, positive regulation of transport|GO:0060255, regulation of macromolecule metabolic process|GO:0060548, negative regulation of cell death|GO:0009914, hormone transport|GO:0045184, establishment of protein localization|GO:0090276, regulation of peptide hormone secretion|GO:0090277, positive regulation of peptide hormone secretion|GO:0007155, cell adhesion|GO:0010038, response to metal ion|GO:0009607, response to biotic stimulus|GO:0010035, response to inorganic substance|GO:0051707, response to other organism|GO:0030168, platelet activation|GO:0003008, system process|GO:0042325, regulation of phosphorylation|GO:0044700, single organism signaling|GO:0042327, positive regulation of phosphorylation|GO:0065008, regulation of biological quality|GO:0051716, cellular response to stimulus|GO:0016192, vesicle-mediated transport|GO:0044707, single-multicellular organism process|GO:0019538, protein metabolic process|GO:0002376, immune system process|GO:0003013, circulatory system process|GO:0050880, regulation of blood vessel size|GO:0098609, cell-cell adhesion|GO:1903530, regulation of secretion by cell|GO:0035150, regulation of tube size|GO:0022607, cellular component assembly|GO:0009893, positive regulation of metabolic process|GO:0006950, response to stress|GO:1903532, positive regulation of secretion by cell|GO:0008104, protein localization|GO:0032940, secretion by cell|GO:0065007, biological regulation|GO:0042742, defense response to bacterium|GO:0042310, vasoconstriction|GO:0035556, intracellular signal transduction|GO:0051223, regulation of protein transport|GO:0042981, regulation of apoptotic process|GO:0050789, regulation of biological process|GO:0030072, peptide hormone secretion|GO:0009605, response to external stimulus|GO:0044267, cellular protein metabolic process|GO:0050708, regulation of protein secretion|GO:0044260, cellular macromolecule metabolic process|GO:0006887, exocytosis|GO:0016043, cellular component organization|GO:0090066, regulation of anatomical structure size|GO:0065003, macromolecular complex assembly|GO:0008015, blood circulation|GO:1904035, regulation of epithelial cell apoptotic process|GO:0071840, cellular component organization or biogenesis|GO:1904036, negative regulation of epithelial cell apoptotic process|GO:0032880, regulation of protein localization|GO:0016265, obsolete death|GO:0009617, response to bacterium|GO:0070201, regulation of establishment of protein localization|GO:0098602, single organism cell adhesion|GO:0009306, protein secretion|GO:0006810, transport|GO:0042886, amide transport|GO:0042060, wound healing|GO:0050794, regulation of cellular process|GO:0043410, positive regulation of MAPK cascade|GO:0012501, programmed cell death|GO:1903524, positive regulation of blood circulation|GO:0050817, coagulation|GO:1903522, regulation of blood circulation|GO:0006464, cellular protein modification process|GO:0051239, regulation of multicellular organismal process|GO:0006955, immune response|GO:1902533, positive regulation of intracellular signal transduction|GO:1902531, regulation of intracellular signal transduction|GO:0006952, defense response|GO:0046903, secretion|GO:0072577, endothelial cell apoptotic process|GO:0043207, response to external biotic stimulus|GO:0050714, positive regulation of protein secretion|GO:0043412, macromolecule modification|GO:0050896, response to stimulus|GO:0031401, positive regulation of protein modification process|GO:0001775, cell activation|GO:0034114, regulation of heterotypic cell-cell adhesion|GO:0036211, protein modification process|GO:0043152, induction of bacterial agglutination|GO:0051046, regulation of secretion|GO:0051240, positive regulation of multicellular organismal process|GO:1902042, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|GO:1902041, regulation of extrinsic apoptotic signaling pathway via death domain receptors|GO:0006461, protein complex assembly|GO:0008152, metabolic process|GO:0070271, protein complex biogenesis|GO:0016310, phosphorylation|GO:0030155, regulation of cell adhesion|GO:0023056, positive regulation of signaling|GO:0023057, negative regulation of signaling|GO:0015833, peptide transport|GO:0023052, signaling|GO:0010648, negative regulation of cell communication|GO:0023051, regulation of signaling|GO:0051592, response to calcium ion|GO:0010647, positive regulation of cell communication|GO:0010646, regulation of cell communication|GO:0044699, single-organism process|GO:0043408, regulation of MAPK cascade|GO:1904019, epithelial cell apoptotic process|GO:0008625, extrinsic apoptotic signaling pathway via death domain receptors|GO:0044057, regulation of system process|GO:0010562, positive regulation of phosphorus metabolic process|GO:0051246, regulation of protein metabolic process|GO:0051247, positive regulation of protein metabolic process|GO:0032270, positive regulation of cellular protein metabolic process|GO:0031399, regulation of protein modification process|GO:0022610, biological adhesion|GO:0017157, regulation of exocytosis|GO:0032501, multicellular organismal process|GO:0050878, regulation of body fluid levels|GO:0031323, regulation of cellular metabolic process|GO:0009987, cellular process|GO:2000351, regulation of endothelial cell apoptotic process|GO:2000352, negative regulation of endothelial cell apoptotic process|GO:0060627, regulation of vesicle-mediated transport|GO:0046883, regulation of hormone secretion|GO:0098542, defense response to other organism|GO:0046887, positive regulation of hormone secretion|GO:0032879, regulation of localization|GO:0051258, protein polymerization|GO:0032268, regulation of cellular protein metabolic process|GO:0090087, regulation of peptide transport|GO:0043170, macromolecule metabolic process|GO:0070374, positive regulation of ERK1 and ERK2 cascade|GO:0070372, regulation of ERK1 and ERK2 cascade|GO:0070371, ERK1 and ERK2 cascade|GO:0045921, positive regulation of exocytosis|GO:0016337, single organismal cell-cell adhesion|GO:0060341, regulation of cellular localization|GO:0043933, macromolecular complex subunit organization|GO:0031325, positive regulation of cellular metabolic process|GO:0097190, apoptotic signaling pathway|GO:0097191, extrinsic apoptotic signaling pathway|GO:0022407, regulation of cell-cell adhesion|GO:0006959, humoral immune response|GO:0034622, cellular macromolecular complex assembly|GO:0051234, establishment of localization|GO:0008219, cell death|GO:0010941, regulation of cell death|GO:0051222, positive regulation of protein transport|GO:0022409, positive regulation of cell-cell adhesion|GO:0042221, response to chemical|GO:0072377, blood coagulation, common pathway|GO:0072376, protein activation cascade|GO:0072378, blood coagulation, fibrin clot formation|GO:0071705, nitrogen compound transport|GO:0071704, organic substance metabolic process|GO:0043067, regulation of programmed cell death|GO:0043066, negative regulation of apoptotic process|GO:0071702, organic substance transport|GO:0051704, multi-organism process|GO:0043069, negative regulation of programmed cell death|GO:0097285, obsolete cell-type specific apoptotic process|GO:0006468, protein phosphorylation|GO:0045937, positive regulation of phosphate metabolic process|GO:0034109, homotypic cell-cell adhesion|GO:0006915, apoptotic process|GO:0023061, signal release|GO:0010817, regulation of hormone levels|GO:0051174, regulation of phosphorus metabolic process|GO:0044765, single-organism transport|GO:0044763, single-organism cellular process|GO:0051649, establishment of localization in cell|GO:0007267, cell-cell signaling|GO:0007154, cell communication|GO:0019730, antimicrobial humoral response|GO:0043623, cellular protein complex assembly|GO:0051179, localization|GO:1902578, single-organism localization|GO:0051641, cellular localization|GO:0044238, primary metabolic process|GO:0071822, protein complex subunit organization|GO:0002790, peptide secretion|GO:0002791, regulation of peptide secretion|GO:0002793, positive regulation of peptide secretion|GO:0044237, cellular metabolic process|GO:0070527, platelet aggregation|GO:0006796, phosphate-containing compound metabolic process|GO:0044085, cellular component biogenesis|GO:0006793, phosphorus metabolic process|GO:0015031, protein transport|GO:0001932, regulation of protein phosphorylation|GO:0001934, positive regulation of protein phosphorylation|GO:0048523, negative regulation of cellular process|GO:0048522, positive regulation of cellular process|GO:0010467, gene expression|GO:1901564, organonitrogen compound metabolic process|GO:0030193, regulation of blood coagulation|GO:0030195, negative regulation of blood coagulation|GO:1900046, regulation of hemostasis|GO:1900047, negative regulation of hemostasis|GO:0050818, regulation of coagulation|GO:0050819, negative regulation of coagulation|GO:0042730, fibrinolysis|GO:0051604, protein maturation|GO:0080134, regulation of response to stress|GO:0032102, negative regulation of response to external stimulus|GO:0032101, regulation of response to external stimulus|GO:1904951, positive regulation of establishment of protein localization|GO:0051241, negative regulation of multicellular organismal process|GO:0006508, proteolysis|GO:1903034, regulation of response to wounding|GO:1903035, negative regulation of response to wounding|GO:0016485, protein processing|GO:0006807, nitrogen compound metabolic process|GO:0061041, regulation of wound healing|GO:0061045, negative regulation of wound healing|GO:0031639, plasminogen activation|GO:0031638, zymogen activation

GO:0009897, external side of plasma membrane|GO:0043229, intracellular organelle|GO:0071944, cell periphery|GO:0098552, side of membrane|GO:0043227, membrane-bounded organelle|GO:0043226, organelle|GO:0005737, cytoplasm|GO:0031091, platelet alpha granule|GO:0070062, extracellular exosome|GO:0016023, cytoplasmic, membrane-bounded vesicle|GO:0031410, cytoplasmic vesicle|GO:0016020, membrane|GO:0044444, cytoplasmic part|GO:0072562, blood microparticle|GO:0031988, membrane-bounded vesicle|GO:0005615, extracellular space|GO:0044459, plasma membrane part|GO:0030141, secretory granule|GO:0009986, cell surface|GO:0005938, cell cortex|GO:0005886, plasma membrane|GO:0032991, macromolecular complex|GO:1903561, extracellular vesicle|GO:0031982, vesicle|GO:0043234, protein complex|GO:0043230, extracellular organelle|GO:0043231, intracellular membrane-bounded organelle|GO:0044464, cell part|GO:0005623, cell|GO:0005622, intracellular|GO:0005577, fibrinogen complex|GO:0005576, extracellular region|GO:0044424, intracellular part|GO:0044425, membrane part|GO:0065010, extracellular membrane-bounded organelle|GO:0044421, extracellular region part|GO:0012505, endomembrane system|GO:0099503, secretory vesicle|GO:0099568, cytoplasmic region|GO:0097708, intracellular vesicle

GO:0030674, protein binding, bridging|GO:0005198, structural molecule activity|GO:0005488, binding|GO:0005515, protein binding|GO:0005102, receptor binding|GO:0050839, cell adhesion molecule binding|GO:0060090, binding, bridging

 

http://www.uniprot.org/uniprot/G1MJI0

FALSE

6

G1LKP1

G1LKP1

ENSAMEG00000007135

1.377829229

    

http://www.uniprot.org/uniprot/G1LKP1

FALSE

7

G1MMG4

G1MMG4

ENSAMEG00000019512

1.299197134

    

http://www.uniprot.org/uniprot/G1MMG4

FALSE

8

G1M4J5

G1M4J5

ENSAMEG00000013547

1.037606126

    

http://www.uniprot.org/uniprot/G1M4J5

FALSE

9

Q7M3C1

Q7M3C1

MB

1.322543678

GO:0006810, transport|GO:0015669, gas transport|GO:0044765, single-organism transport|GO:0015671, oxygen transport|GO:1902578, single-organism localization|GO:0051234, establishment of localization|GO:0051179, localization|GO:0044699, single-organism process

 

GO:0043169, cation binding|GO:0005344, oxygen transporter activity|GO:0022892, substrate-specific transporter activity|GO:0046914, transition metal ion binding|GO:0020037, heme binding|GO:0046906, tetrapyrrole binding|GO:0005215, transporter activity|GO:0043167, ion binding|GO:0019825, oxygen binding|GO:0005488, binding|GO:0097159, organic cyclic compound binding|GO:0005506, iron ion binding|GO:0046872, metal ion binding|GO:1901363, heterocyclic compound binding

 

http://www.uniprot.org/uniprot/Q7M3C1

FALSE

10

G1KZU2

G1KZU2

POSTN

− 1.081168123

GO:0048583, regulation of response to stimulus|GO:0023052, signaling|GO:0007165, signal transduction|GO:0007166, cell surface receptor signaling pathway|GO:0023051, regulation of signaling|GO:0010646, regulation of cell communication|GO:0050789, regulation of biological process|GO:0071840, cellular component organization or biogenesis|GO:0051716, cellular response to stimulus|GO:0007219, Notch signaling pathway|GO:0009966, regulation of signal transduction|GO:0016043, cellular component organization|GO:0065007, biological regulation|GO:0044699, single-organism process|GO:0043062, extracellular structure organization|GO:0022610, biological adhesion|GO:0032502, developmental process|GO:0009987, cellular process|GO:0009888, tissue development|GO:0050794, regulation of cellular process|GO:0044763, single-organism cellular process|GO:0008593, regulation of Notch signaling pathway|GO:0007155, cell adhesion|GO:0007154, cell communication|GO:0044700, single organism signaling|GO:0050896, response to stimulus|GO:0048856, anatomical structure development|GO:0030198, extracellular matrix organization|GO:0009991, response to extracellular stimulus|GO:0070887, cellular response to chemical stimulus|GO:0071295, cellular response to vitamin|GO:0031670, cellular response to nutrient|GO:1901655, cellular response to ketone|GO:0033273, response to vitamin|GO:0071496, cellular response to external stimulus|GO:0032571, response to vitamin K|GO:1901701, cellular response to oxygen-containing compound|GO:0007584, response to nutrient|GO:0042221, response to chemical|GO:0010033, response to organic substance|GO:1901700, response to oxygen-containing compound|GO:0031668, cellular response to extracellular stimulus|GO:0031669, cellular response to nutrient levels|GO:0009605, response to external stimulus|GO:0031667, response to nutrient levels|GO:1901654, response to ketone|GO:0071307, cellular response to vitamin K

GO:0031012, extracellular matrix|GO:0043229, intracellular organelle|GO:0043227, membrane-bounded organelle|GO:0043226, organelle|GO:0005737, cytoplasm|GO:0031984, organelle subcompartment|GO:0044431, Golgi apparatus part|GO:0005794, Golgi apparatus|GO:0012505, endomembrane system|GO:0043231, intracellular membrane-bounded organelle|GO:0005802, trans-Golgi network|GO:0044464, cell part|GO:0005623, cell|GO:0005622, intracellular|GO:0044446, intracellular organelle part|GO:0044444, cytoplasmic part|GO:0005576, extracellular region|GO:0098791, Golgi subcompartment|GO:0005578, proteinaceous extracellular matrix|GO:0044424, intracellular part|GO:0044421, extracellular region part|GO:0044422, organelle part|GO:0005615, extracellular space

GO:1901681, sulfur compound binding|GO:0043168, anion binding|GO:0097367, carbohydrate derivative binding|GO:0043167, ion binding|GO:0005539, glycosaminoglycan binding|GO:0005488, binding|GO:0008201, heparin binding|GO:0043169, cation binding|GO:0046872, metal ion binding

 

http://www.uniprot.org/uniprot/G1KZU2

FALSE

11

D2H7X8

D2H7X8

FTL

1.799120339

GO:0050801, ion homeostasis|GO:0042592, homeostatic process|GO:0055072, iron ion homeostasis|GO:0006826, iron ion transport|GO:0055076, transition metal ion homeostasis|GO:0098771, inorganic ion homeostasis|GO:0044699, single-organism process|GO:0046916, cellular transition metal ion homeostasis|GO:0000041, transition metal ion transport|GO:0065007, biological regulation|GO:0065008, regulation of biological quality|GO:0019725, cellular homeostasis|GO:0006810, transport|GO:0006879, cellular iron ion homeostasis|GO:0006875, cellular metal ion homeostasis|GO:0006812, cation transport|GO:0006811, ion transport|GO:0009987, cellular process|GO:0006873, cellular ion homeostasis|GO:0044765, single-organism transport|GO:0044763, single-organism cellular process|GO:0030003, cellular cation homeostasis|GO:0055065, metal ion homeostasis|GO:0055080, cation homeostasis|GO:0055082, cellular chemical homeostasis|GO:0051234, establishment of localization|GO:0051179, localization|GO:1902578, single-organism localization|GO:0048878, chemical homeostasis|GO:0030001, metal ion transport

GO:0005623, cell

GO:0043169, cation binding|GO:0046914, transition metal ion binding|GO:0043167, ion binding|GO:0008199, ferric iron binding|GO:0005488, binding|GO:0005506, iron ion binding|GO:0046872, metal ion binding

aml04978, Mineral absorption

http://www.uniprot.org/uniprot/D2H7X8

FALSE

12

G1MKA5

G1MKA5

ENSAMEG00000018739

1.666462743

    

http://www.uniprot.org/uniprot/G1MKA5

FALSE

13

G1LQ06

G1LQ06

ENSAMEG00000008683

1.017268912

    

http://www.uniprot.org/uniprot/G1LQ06

FALSE

14

G1MIQ3

G1MIQ3

SAAL1

3.369050286

GO:0050896, response to stimulus|GO:0006952, defense response|GO:0006953, acute-phase response|GO:0006950, response to stress|GO:0006954, inflammatory response|GO:0002526, acute inflammatory response

GO:0005576, extracellular region

  

http://www.uniprot.org/uniprot/G1MIQ3

FALSE

15

G1MJI1

G1MJI1

FGG

1.510917875

GO:2001234, negative regulation of apoptotic signaling pathway|GO:0034116, positive regulation of heterotypic cell-cell adhesion|GO:2001236, regulation of extrinsic apoptotic signaling pathway|GO:2001237, negative regulation of extrinsic apoptotic signaling pathway|GO:0019220, regulation of phosphate metabolic process|GO:0080090, regulation of primary metabolic process|GO:0019222, regulation of metabolic process|GO:2001233, regulation of apoptotic signaling pathway|GO:0051049, regulation of transport|GO:0048585, negative regulation of response to stimulus|GO:0048584, positive regulation of response to stimulus|GO:0048583, regulation of response to stimulus|GO:0019229, regulation of vasoconstriction|GO:0007160, cell-matrix adhesion|GO:0045907, positive regulation of vasoconstriction|GO:0007165, signal transduction|GO:0007166, cell surface receptor signaling pathway|GO:0003018, vascular process in circulatory system|GO:0034113, heterotypic cell-cell adhesion|GO:0023014, signal transduction by protein phosphorylation|GO:0044710, single-organism metabolic process|GO:0010604, positive regulation of macromolecule metabolic process|GO:0009968, negative regulation of signal transduction|GO:0045785, positive regulation of cell adhesion|GO:0009966, regulation of signal transduction|GO:0009967, positive regulation of signal transduction|GO:0051047, positive regulation of secretion|GO:0000165, MAPK cascade|GO:0009611, response to wounding|GO:0046879, hormone secretion|GO:0048518, positive regulation of biological process|GO:0048519, negative regulation of biological process|GO:0033036, macromolecule localization|GO:0007599, hemostasis|GO:0031589, cell-substrate adhesion|GO:0007596, blood coagulation|GO:0051050, positive regulation of transport|GO:0060255, regulation of macromolecule metabolic process|GO:0060548, negative regulation of cell death|GO:0009914, hormone transport|GO:0045184, establishment of protein localization|GO:0090276, regulation of peptide hormone secretion|GO:0090277, positive regulation of peptide hormone secretion|GO:0007155, cell adhesion|GO:0010038, response to metal ion|GO:0010035, response to inorganic substance|GO:0030168, platelet activation|GO:0003008, system process|GO:0042325, regulation of phosphorylation|GO:0044700, single organism signaling|GO:0042327, positive regulation of phosphorylation|GO:0065008, regulation of biological quality|GO:0051716, cellular response to stimulus|GO:0016192, vesicle-mediated transport|GO:0044707, single-multicellular organism process|GO:0019538, protein metabolic process|GO:0003013, circulatory system process|GO:0050880, regulation of blood vessel size|GO:0098609, cell-cell adhesion|GO:1903530, regulation of secretion by cell|GO:0035150, regulation of tube size|GO:0022607, cellular component assembly|GO:0009893, positive regulation of metabolic process|GO:0006950, response to stress|GO:1903532, positive regulation of secretion by cell|GO:0008104, protein localization|GO:0032940, secretion by cell|GO:0065007, biological regulation|GO:0042310, vasoconstriction|GO:0035556, intracellular signal transduction|GO:0051223, regulation of protein transport|GO:0042981, regulation of apoptotic process|GO:0050789, regulation of biological process|GO:0030072, peptide hormone secretion|GO:0044267, cellular protein metabolic process|GO:0050708, regulation of protein secretion|GO:0044260, cellular macromolecule metabolic process|GO:0006887, exocytosis|GO:0016043, cellular component organization|GO:0090066, regulation of anatomical structure size|GO:0065003, macromolecular complex assembly|GO:0008015, blood circulation|GO:1904035, regulation of epithelial cell apoptotic process|GO:0071840, cellular component organization or biogenesis|GO:1904036, negative regulation of epithelial cell apoptotic process|GO:0032880, regulation of protein localization|GO:0016265, obsolete death|GO:0070201, regulation of establishment of protein localization|GO:0098602, single organism cell adhesion|GO:0009306, protein secretion|GO:0006810, transport|GO:0042886, amide transport|GO:0042060, wound healing|GO:0050794, regulation of cellular process|GO:0043410, positive regulation of MAPK cascade|GO:0012501, programmed cell death|GO:1903524, positive regulation of blood circulation|GO:0050817, coagulation|GO:1903522, regulation of blood circulation|GO:0006464, cellular protein modification process|GO:0051239, regulation of multicellular organismal process|GO:1902533, positive regulation of intracellular signal transduction|GO:1902531, regulation of intracellular signal transduction|GO:0046903, secretion|GO:0072577, endothelial cell apoptotic process|GO:0050714, positive regulation of protein secretion|GO:0043412, macromolecule modification|GO:0050896, response to stimulus|GO:0031401, positive regulation of protein modification process|GO:0001775, cell activation|GO:0034114, regulation of heterotypic cell-cell adhesion|GO:0036211, protein modification process|GO:0051046, regulation of secretion|GO:0051240, positive regulation of multicellular organismal process|GO:1902042, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|GO:1902041, regulation of extrinsic apoptotic signaling pathway via death domain receptors|GO:0006461, protein complex assembly|GO:0008152, metabolic process|GO:0070271, protein complex biogenesis|GO:0016310, phosphorylation|GO:0030155, regulation of cell adhesion|GO:0023056, positive regulation of signaling|GO:0023057, negative regulation of signaling|GO:0015833, peptide transport|GO:0023052, signaling|GO:0010648, negative regulation of cell communication|GO:0023051, regulation of signaling|GO:0051592, response to calcium ion|GO:0010647, positive regulation of cell communication|GO:0010646, regulation of cell communication|GO:0044699, single-organism process|GO:0043408, regulation of MAPK cascade|GO:1904019, epithelial cell apoptotic process|GO:0008625, extrinsic apoptotic signaling pathway via death domain receptors|GO:0044057, regulation of system process|GO:0010562, positive regulation of phosphorus metabolic process|GO:0051246, regulation of protein metabolic process|GO:0051247, positive regulation of protein metabolic process|GO:0032270, positive regulation of cellular protein metabolic process|GO:0031399, regulation of protein modification process|GO:0022610, biological adhesion|GO:0017157, regulation of exocytosis|GO:0032501, multicellular organismal process|GO:0050878, regulation of body fluid levels|GO:0031323, regulation of cellular metabolic process|GO:0009987, cellular process|GO:2000351, regulation of endothelial cell apoptotic process|GO:2000352, negative regulation of endothelial cell apoptotic process|GO:0060627, regulation of vesicle-mediated transport|GO:0046883, regulation of hormone secretion|GO:0046887, positive regulation of hormone secretion|GO:0032879, regulation of localization|GO:0051258, protein polymerization|GO:0032268, regulation of cellular protein metabolic process|GO:0090087, regulation of peptide transport|GO:0043170, macromolecule metabolic process|GO:0070374, positive regulation of ERK1 and ERK2 cascade|GO:0070372, regulation of ERK1 and ERK2 cascade|GO:0070371, ERK1 and ERK2 cascade|GO:0045921, positive regulation of exocytosis|GO:0016337, single organismal cell-cell adhesion|GO:0060341, regulation of cellular localization|GO:0043933, macromolecular complex subunit organization|GO:0031325, positive regulation of cellular metabolic process|GO:0097190, apoptotic signaling pathway|GO:0097191, extrinsic apoptotic signaling pathway|GO:0022407, regulation of cell-cell adhesion|GO:0034622, cellular macromolecular complex assembly|GO:0051234, establishment of localization|GO:0008219, cell death|GO:0010941, regulation of cell death|GO:0051222, positive regulation of protein transport|GO:0022409, positive regulation of cell-cell adhesion|GO:0042221, response to chemical|GO:0071822, protein complex subunit organization|GO:0071705, nitrogen compound transport|GO:0071704, organic substance metabolic process|GO:0043067, regulation of programmed cell death|GO:0043066, negative regulation of apoptotic process|GO:0071702, organic substance transport|GO:0043069, negative regulation of programmed cell death|GO:0097285, obsolete cell-type specific apoptotic process|GO:0006468, protein phosphorylation|GO:0045937, positive regulation of phosphate metabolic process|GO:0034109, homotypic cell-cell adhesion|GO:0006915, apoptotic process|GO:0023061, signal release|GO:0010817, regulation of hormone levels|GO:0051174, regulation of phosphorus metabolic process|GO:0044765, single-organism transport|GO:0044763, single-organism cellular process|GO:0051649, establishment of localization in cell|GO:0007267, cell-cell signaling|GO:0007154, cell communication|GO:0043623, cellular protein complex assembly|GO:0051179, localization|GO:1902578, single-organism localization|GO:0051641, cellular localization|GO:0044238, primary metabolic process|GO:0002790, peptide secretion|GO:0002791, regulation of peptide secretion|GO:0002793, positive regulation of peptide secretion|GO:0044237, cellular metabolic process|GO:0070527, platelet aggregation|GO:0006796, phosphate-containing compound metabolic process|GO:0044085, cellular component biogenesis|GO:0006793, phosphorus metabolic process|GO:0015031, protein transport|GO:0001932, regulation of protein phosphorylation|GO:0001934, positive regulation of protein phosphorylation|GO:0048523, negative regulation of cellular process|GO:0048522, positive regulation of cellular process|GO:0010467, gene expression|GO:1901564, organonitrogen compound metabolic process|GO:0030193, regulation of blood coagulation|GO:0030195, negative regulation of blood coagulation|GO:1900046, regulation of hemostasis|GO:1900047, negative regulation of hemostasis|GO:0050818, regulation of coagulation|GO:0050819, negative regulation of coagulation|GO:0042730, fibrinolysis|GO:0051604, protein maturation|GO:0080134, regulation of response to stress|GO:0032102, negative regulation of response to external stimulus|GO:0032101, regulation of response to external stimulus|GO:1904951, positive regulation of establishment of protein localization|GO:0051241, negative regulation of multicellular organismal process|GO:0006508, proteolysis|GO:1903034, regulation of response to wounding|GO:1903035, negative regulation of response to wounding|GO:0016485, protein processing|GO:0006807, nitrogen compound metabolic process|GO:0061041, regulation of wound healing|GO:0061045, negative regulation of wound healing|GO:0072376, protein activation cascade|GO:0072378, blood coagulation, fibrin clot formation|GO:0031639, plasminogen activation|GO:0031638, zymogen activation|GO:0009605, response to external stimulus

GO:0009897, external side of plasma membrane|GO:0043229, intracellular organelle|GO:0071944, cell periphery|GO:0098552, side of membrane|GO:0043227, membrane-bounded organelle|GO:0043226, organelle|GO:0005737, cytoplasm|GO:0031091, platelet alpha granule|GO:0070062, extracellular exosome|GO:0016023, cytoplasmic, membrane-bounded vesicle|GO:0031410, cytoplasmic vesicle|GO:0016020, membrane|GO:0044444, cytoplasmic part|GO:0072562, blood microparticle|GO:0031988, membrane-bounded vesicle|GO:0005615, extracellular space|GO:0044459, plasma membrane part|GO:0030141, secretory granule|GO:0009986, cell surface|GO:0005938, cell cortex|GO:0005886, plasma membrane|GO:0032991, macromolecular complex|GO:1903561, extracellular vesicle|GO:0031982, vesicle|GO:0043234, protein complex|GO:0043230, extracellular organelle|GO:0043231, intracellular membrane-bounded organelle|GO:0044464, cell part|GO:0005623, cell|GO:0005622, intracellular|GO:0005577, fibrinogen complex|GO:0005576, extracellular region|GO:0044424, intracellular part|GO:0044425, membrane part|GO:0065010, extracellular membrane-bounded organelle|GO:0044421, extracellular region part|GO:0012505, endomembrane system|GO:0099503, secretory vesicle|GO:0097708, intracellular vesicle

GO:0030674, protein binding, bridging|GO:0005198, structural molecule activity|GO:0005488, binding|GO:0005515, protein binding|GO:0005102, receptor binding|GO:0050839, cell adhesion molecule binding|GO:0060090, binding, bridging

 

http://www.uniprot.org/uniprot/G1MJI1

FALSE

16

D2GUY3

D2GUY3

TPM4

− 1.185094746

GO:0032502, developmental process|GO:0032501, multicellular organismal process|GO:0044707, single-multicellular organism process|GO:0048869, cellular developmental process|GO:0030154, cell differentiation|GO:0044767, single-organism developmental process|GO:0001503, ossification|GO:0044763, single-organism cellular process|GO:0044699, single-organism process|GO:0009987, cellular process|GO:0001649, osteoblast differentiation

GO:0032432, actin filament bundle|GO:0015629, actin cytoskeleton|GO:0043229, intracellular organelle|GO:0043228, non-membrane-bounded organelle|GO:0005924, cell-substrate adherens junction|GO:0005925, focal adhesion|GO:0043227, membrane-bounded organelle|GO:0043226, organelle|GO:0030054, cell junction|GO:0042641, actomyosin|GO:0005856, cytoskeleton|GO:0001725, stress fiber|GO:0005938, cell cortex|GO:0002102, podosome|GO:0031982, vesicle|GO:0016020, membrane|GO:0031988, membrane-bounded vesicle|GO:0044430, cytoskeletal part|GO:0030055, cell-substrate junction|GO:0005576, extracellular region|GO:0005737, cytoplasm|GO:0031941, filamentous actin|GO:0070161, anchoring junction|GO:0005884, actin filament|GO:0032991, macromolecular complex|GO:1903561, extracellular vesicle|GO:0070062, extracellular exosome|GO:0043234, protein complex|GO:0043230, extracellular organelle|GO:0043232, intracellular non-membrane-bounded organelle|GO:0030863, cortical cytoskeleton|GO:0044464, cell part|GO:0005623, cell|GO:0005622, intracellular|GO:0044446, intracellular organelle part|GO:0044444, cytoplasmic part|GO:0071944, cell periphery|GO:0044448, cell cortex part|GO:0044424, intracellular part|GO:0065010, extracellular membrane-bounded organelle|GO:0044421, extracellular region part|GO:0044422, organelle part|GO:0005912, adherens junction|GO:0099512, supramolecular fiber|GO:0097517, contractile actin filament bundle|GO:0099568, cytoplasmic region|GO:0099513, polymeric cytoskeletal fiber

 

aml05410, Hypertrophic cardiomyopathy (HCM)|aml05414, Dilated cardiomyopathy|aml04260, Cardiac muscle contraction|aml04261, Adrenergic signaling in cardiomyocytes

http://www.uniprot.org/uniprot/D2GUY3

FALSE

17

G1L780

G1L780

ENSAMEG00000002626

1.543822928

    

http://www.uniprot.org/uniprot/G1L780

FALSE

18

G1KZS5

G1KZS5

LOC100483473

1.337494957

    

http://www.uniprot.org/uniprot/G1KZS5

FALSE

19

G1LSF9

G1LSF9

ENSAMEG00000009525

1.415438304

    

http://www.uniprot.org/uniprot/G1LSF9

FALSE

20

G1MJV9

G1MJV9

ENSAMEG00000018591

1.394244417

    

http://www.uniprot.org/uniprot/G1MJV9

FALSE

21

G1LKE7

G1LKE7

ENSAMEG00000007039

1.603611757

    

http://www.uniprot.org/uniprot/G1LKE7

FALSE

22

G1M4V6

G1M4V6

FGL1

1.318851165

 

GO:0043230, extracellular organelle|GO:0031982, vesicle|GO:0044421, extracellular region part|GO:0043227, membrane-bounded organelle|GO:0031988, membrane-bounded vesicle|GO:0005576, extracellular region|GO:1903561, extracellular vesicle|GO:0065010, extracellular membrane-bounded organelle|GO:0043226, organelle|GO:0070062, extracellular exosome

  

http://www.uniprot.org/uniprot/G1M4V6

FALSE

23

G1M8B3

G1M8B3

IGFBP1

2.41111805

GO:0016049, cell growth|GO:0040007, growth|GO:0040008, regulation of growth|GO:0009987, cellular process|GO:0016043, cellular component organization|GO:0050794, regulation of cellular process|GO:0001558, regulation of cell growth|GO:0044763, single-organism cellular process|GO:0071840, cellular component organization or biogenesis|GO:0065007, biological regulation|GO:0051128, regulation of cellular component organization|GO:0050789, regulation of biological process|GO:0044699, single-organism process

GO:0005576, extracellular region|GO:0005615, extracellular space|GO:0044421, extracellular region part|GO:0005737, cytoplasm|GO:0005794, Golgi apparatus|GO:0043231, intracellular membrane-bounded organelle|GO:0044464, cell part|GO:0044444, cytoplasmic part|GO:0005623, cell|GO:0005622, intracellular|GO:0043229, intracellular organelle|GO:0012505, endomembrane system|GO:0044424, intracellular part|GO:0043227, membrane-bounded organelle|GO:0043226, organelle

GO:0005520, insulin-like growth factor binding|GO:0019838, growth factor binding|GO:0005515, protein binding|GO:0005488, binding|GO:0031994, insulin-like growth factor I binding|GO:0031995, insulin-like growth factor II binding

 

http://www.uniprot.org/uniprot/G1M8B3

FALSE

24

G1L3J9

G1L3J9

CAMP

1.689489419

GO:0006952, defense response|GO:0006950, response to stress|GO:0050896, response to stimulus|GO:0045926, negative regulation of growth|GO:0044139, modulation of growth of symbiont on or near host|GO:0044110, growth involved in symbiotic interaction|GO:0042742, defense response to bacterium|GO:0044116, growth of symbiont involved in interaction with host|GO:0044117, growth of symbiont in host|GO:0050829, defense response to Gram-negative bacterium|GO:0050789, regulation of biological process|GO:0044130, negative regulation of growth of symbiont in host|GO:0044140, negative regulation of growth of symbiont on or near host surface|GO:0040007, growth|GO:0043207, response to external biotic stimulus|GO:0044364, disruption of cells of other organism|GO:0040008, regulation of growth|GO:0009617, response to bacterium|GO:0051852, disruption by host of symbiont cells|GO:0051851, modification by host of symbiont morphology or physiology|GO:0044133, growth of symbiont on or near host|GO:0044419, interspecies interaction between organisms|GO:0065007, biological regulation|GO:0051873, killing by host of symbiont cells|GO:0048519, negative regulation of biological process|GO:0001906, cell killing|GO:0051818, disruption of cells of other organism involved in symbiotic interaction|GO:0051704, multi-organism process|GO:0045087, innate immune response|GO:0043903, regulation of symbiosis, encompassing mutualism through parasitism|GO:0043900, regulation of multi-organism process|GO:0043901, negative regulation of multi-organism process|GO:0098542, defense response to other organism|GO:0006955, immune response|GO:0051702, interaction with symbiont|GO:0044126, regulation of growth of symbiont in host|GO:0051707, response to other organism|GO:0044146, negative regulation of growth of symbiont involved in interaction with host|GO:0044144, modulation of growth of symbiont involved in interaction with host|GO:0009607, response to biotic stimulus|GO:0009605, response to external stimulus|GO:0051883, killing of cells in other organism involved in symbiotic interaction|GO:0031640, killing of cells of other organism|GO:0050830, defense response to Gram-positive bacterium|GO:0002376, immune system process|GO:0044403, symbiosis, encompassing mutualism through parasitism|GO:0035821, modification of morphology or physiology of other organism|GO:0051817, modification of morphology or physiology of other organism involved in symbiotic interaction

GO:0005576, extracellular region|GO:0005737, cytoplasm|GO:0012505, endomembrane system|GO:0043231, intracellular membrane-bounded organelle|GO:0099503, secretory vesicle|GO:0016023, cytoplasmic, membrane-bounded vesicle|GO:0030141, secretory granule|GO:0044464, cell part|GO:0044444, cytoplasmic part|GO:0005623, cell|GO:0031988, membrane-bounded vesicle|GO:0042581, specific granule|GO:0043229, intracellular organelle|GO:0097708, intracellular vesicle|GO:0031410, cytoplasmic vesicle|GO:0044424, intracellular part|GO:0005622, intracellular|GO:0043227, membrane-bounded organelle|GO:0043226, organelle|GO:0031982, vesicle

  

http://www.uniprot.org/uniprot/G1L3J9

FALSE

25

G1M307

G1M307

RGN

1.0231726

GO:0019222, regulation of metabolic process|GO:0050790, regulation of catalytic activity|GO:0065007, biological regulation|GO:0008152, metabolic process|GO:0065009, regulation of molecular function|GO:0050789, regulation of biological process

 

GO:0043169, cation binding|GO:0098772, molecular function regulator|GO:0030234, enzyme regulator activity|GO:0043167, ion binding|GO:0005509, calcium ion binding|GO:0046872, metal ion binding|GO:0005488, binding

aml00053, Ascorbate and aldarate metabolism|aml01200, Carbon metabolism|aml01100, Metabolic pathways|aml00030, Pentose phosphate pathway

http://www.uniprot.org/uniprot/G1M307

FALSE

26

G1LGI1

G1LGI1

BHMT

2.041739123

GO:0044272, sulfur compound biosynthetic process|GO:0071267, L-methionine salvage|GO:0019752, carboxylic acid metabolic process|GO:0071265, L-methionine biosynthetic process|GO:0044249, cellular biosynthetic process|GO:0034641, cellular nitrogen compound metabolic process|GO:0006807, nitrogen compound metabolic process|GO:0009067, aspartate family amino acid biosynthetic process|GO:0009066, aspartate family amino acid metabolic process|GO:0044283, small molecule biosynthetic process|GO:0044699, single-organism process|GO:1901576, organic substance biosynthetic process|GO:0044710, single-organism metabolic process|GO:0044711, single-organism biosynthetic process|GO:0006520, cellular amino acid metabolic process|GO:0071704, organic substance metabolic process|GO:0043102, amino acid salvage|GO:0032259, methylation|GO:1901605, alpha-amino acid metabolic process|GO:1901607, alpha-amino acid biosynthetic process|GO:0009987, cellular process|GO:0044238, primary metabolic process|GO:0000097, sulfur amino acid biosynthetic process|GO:0000096, sulfur amino acid metabolic process|GO:0009058, biosynthetic process|GO:0044763, single-organism cellular process|GO:0008152, metabolic process|GO:0043436, oxoacid metabolic process|GO:0043094, cellular metabolic compound salvage|GO:0008652, cellular amino acid biosynthetic process|GO:1901564, organonitrogen compound metabolic process|GO:1901566, organonitrogen compound biosynthetic process|GO:0006082, organic acid metabolic process|GO:0006577, amino-acid betaine metabolic process|GO:0046394, carboxylic acid biosynthetic process|GO:0006555, methionine metabolic process|GO:0016053, organic acid biosynthetic process|GO:0044237, cellular metabolic process|GO:0006790, sulfur compound metabolic process|GO:0009086, methionine biosynthetic process|GO:0044281, small molecule metabolic process

GO:0005737, cytoplasm|GO:0005622, intracellular|GO:0043230, extracellular organelle|GO:0031982, vesicle|GO:0044421, extracellular region part|GO:0043227, membrane-bounded organelle|GO:0044464, cell part|GO:0005623, cell|GO:0031988, membrane-bounded vesicle|GO:0005576, extracellular region|GO:0044424, intracellular part|GO:1903561, extracellular vesicle|GO:0065010, extracellular membrane-bounded organelle|GO:0043226, organelle|GO:0070062, extracellular exosome|GO:0005829, cytosol|GO:0044444, cytoplasmic part

GO:0043169, cation binding|GO:0008898, S-adenosylmethionine-homocysteine S-methyltransferase activity|GO:0046914, transition metal ion binding|GO:0008757, S-adenosylmethionine-dependent methyltransferase activity|GO:0043167, ion binding|GO:0008172, S-methyltransferase activity|GO:0003824, catalytic activity|GO:0016740, transferase activity|GO:0016741, transferase activity, transferring one-carbon groups|GO:0008270, zinc ion binding|GO:0047150, betaine-homocysteine S-methyltransferase activity|GO:0008168, methyltransferase activity|GO:0046872, metal ion binding|GO:0005488, binding

aml00260, Glycine, serine and threonine metabolism|aml01100, Metabolic pathways|aml00270, Cysteine and methionine metabolism

http://www.uniprot.org/uniprot/G1LGI1

FALSE

27

G1LUE9

G1LUE9

IGKV4-1

1.634152524

 

GO:0005576, extracellular region|GO:0005615, extracellular space|GO:0072562, blood microparticle|GO:0044421, extracellular region part|GO:0043230, extracellular organelle|GO:0070062, extracellular exosome|GO:1903561, extracellular vesicle|GO:0043227, membrane-bounded organelle|GO:0043226, organelle|GO:0031982, vesicle

  

http://www.uniprot.org/uniprot/G1LUE9

FALSE

28

G1LXP2

G1LXP2

WHSC1L1

1.396286325

GO:0006479, protein methylation|GO:0080090, regulation of primary metabolic process|GO:0019222, regulation of metabolic process|GO:0051568, histone H3-K4 methylation|GO:1901362, organic cyclic compound biosynthetic process|GO:1901360, organic cyclic compound metabolic process|GO:0044710, single-organism metabolic process|GO:0010605, negative regulation of macromolecule metabolic process|GO:0018193, peptidyl-amino acid modification|GO:0016571, histone methylation|GO:0016570, histone modification|GO:0060255, regulation of macromolecule metabolic process|GO:2001141, regulation of RNA biosynthetic process|GO:0046483, heterocycle metabolic process|GO:0070734, histone H3-K27 methylation|GO:0019538, protein metabolic process|GO:0018205, peptidyl-lysine modification|GO:0019438, aromatic compound biosynthetic process|GO:0016568, chromatin modification|GO:0016569, covalent chromatin modification|GO:0009892, negative regulation of metabolic process|GO:0009890, negative regulation of biosynthetic process|GO:0018022, peptidyl-lysine methylation|GO:0010629, negative regulation of gene expression|GO:0006807, nitrogen compound metabolic process|GO:0050789, regulation of biological process|GO:0097659, nucleic acid-templated transcription|GO:1901576, organic substance biosynthetic process|GO:0044260, cellular macromolecule metabolic process|GO:0016043, cellular component organization|GO:0065007, biological regulation|GO:0071840, cellular component organization or biogenesis|GO:0032259, methylation|GO:0018130, heterocycle biosynthetic process|GO:0009889, regulation of biosynthetic process|GO:0050794, regulation of cellular process|GO:0043412, macromolecule modification|GO:0036211, protein modification process|GO:0043414, macromolecule methylation|GO:0008152, metabolic process|GO:0034654, nucleobase-containing compound biosynthetic process|GO:0016070, RNA metabolic process|GO:0044271, cellular nitrogen compound biosynthetic process|GO:0006355, regulation of transcription, DNA-templated|GO:0010556, regulation of macromolecule biosynthetic process|GO:0006351, transcription, DNA-templated|GO:0010558, negative regulation of macromolecule biosynthetic process|GO:0032774, RNA biosynthetic process|GO:0044249, cellular biosynthetic process|GO:0034641, cellular nitrogen compound metabolic process|GO:0034645, cellular macromolecule biosynthetic process|GO:0044699, single-organism process|GO:0006139, nucleobase-containing compound metabolic process|GO:0043933, macromolecular complex subunit organization|GO:0034968, histone lysine methylation|GO:0009987, cellular process|GO:0006725, cellular aromatic compound metabolic process|GO:1903506, regulation of nucleic acid-templated transcription|GO:1903507, negative regulation of nucleic acid-templated transcription|GO:0045892, negative regulation of transcription, DNA-templated|GO:0048519, negative regulation of biological process|GO:0008213, protein alkylation|GO:0051253, negative regulation of RNA metabolic process|GO:0051252, regulation of RNA metabolic process|GO:0043170, macromolecule metabolic process|GO:0031327, negative regulation of cellular biosynthetic process|GO:0031326, regulation of cellular biosynthetic process|GO:0031324, negative regulation of cellular metabolic process|GO:0031323, regulation of cellular metabolic process|GO:0090304, nucleic acid metabolic process|GO:0006325, chromatin organization|GO:2000112, regulation of cellular macromolecule biosynthetic process|GO:2000113, negative regulation of cellular macromolecule biosynthetic process|GO:0071704, organic substance metabolic process|GO:0010467, gene expression|GO:0010468, regulation of gene expression|GO:0045934, negative regulation of nucleobase-containing compound metabolic process|GO:0044267, cellular protein metabolic process|GO:0019219, regulation of nucleobase-containing compound metabolic process|GO:0006464, cellular protein modification process|GO:1902679, negative regulation of RNA biosynthetic process|GO:0009058, biosynthetic process|GO:0009059, macromolecule biosynthetic process|GO:0044763, single-organism cellular process|GO:0051171, regulation of nitrogen compound metabolic process|GO:0051172, negative regulation of nitrogen compound metabolic process|GO:0006996, organelle organization|GO:0044238, primary metabolic process|GO:0051276, chromosome organization|GO:0044237, cellular metabolic process|GO:1902589, single-organism organelle organization|GO:0048523, negative regulation of cellular process|GO:1901564, organonitrogen compound metabolic process

GO:0043231, intracellular membrane-bounded organelle|GO:0005634, nucleus|GO:0044464, cell part|GO:0005623, cell|GO:0005622, intracellular|GO:0043229, intracellular organelle|GO:0044424, intracellular part|GO:0043227, membrane-bounded organelle|GO:0043226, organelle

GO:0018024, histone-lysine N-methyltransferase activity|GO:0043167, ion binding|GO:0042054, histone methyltransferase activity|GO:0046914, transition metal ion binding|GO:0003824, catalytic activity|GO:0008757, S-adenosylmethionine-dependent methyltransferase activity|GO:0043169, cation binding|GO:0016740, transferase activity|GO:0016278, lysine N-methyltransferase activity|GO:0016279, protein-lysine N-methyltransferase activity|GO:0016741, transferase activity, transferring one-carbon groups|GO:0008170, N-methyltransferase activity|GO:0008276, protein methyltransferase activity|GO:0008270, zinc ion binding|GO:0046976, histone methyltransferase activity (H3-K27 specific)|GO:0008168, methyltransferase activity|GO:0046872, metal ion binding|GO:0042800, histone methyltransferase activity (H3-K4 specific)|GO:0005488, binding

 

http://www.uniprot.org/uniprot/G1LXP2

FALSE

29

G1MEC8

G1MEC8

NPAT

− 2.308730386

GO:0080090, regulation of primary metabolic process|GO:0019222, regulation of metabolic process|GO:0000082, G1/S transition of mitotic cell cycle|GO:0000083, regulation of transcription involved in G1/S transition of mitotic cell cycle|GO:1901362, organic cyclic compound biosynthetic process|GO:1901360, organic cyclic compound metabolic process|GO:0010605, negative regulation of macromolecule metabolic process|GO:0010604, positive regulation of macromolecule metabolic process|GO:0048518, positive regulation of biological process|GO:0048519, negative regulation of biological process|GO:0060255, regulation of macromolecule metabolic process|GO:2001141, regulation of RNA biosynthetic process|GO:0046483, heterocycle metabolic process|GO:0019438, aromatic compound biosynthetic process|GO:0009892, negative regulation of metabolic process|GO:0009893, positive regulation of metabolic process|GO:0009890, negative regulation of biosynthetic process|GO:0009891, positive regulation of biosynthetic process|GO:0010628, positive regulation of gene expression|GO:0050789, regulation of biological process|GO:0097659, nucleic acid-templated transcription|GO:0045934, negative regulation of nucleobase-containing compound metabolic process|GO:1901576, organic substance biosynthetic process|GO:0044260, cellular macromolecule metabolic process|GO:0065007, biological regulation|GO:0044699, single-organism process|GO:0006366, transcription from RNA polymerase II promoter|GO:0018130, heterocycle biosynthetic process|GO:0009889, regulation of biosynthetic process|GO:0050794, regulation of cellular process|GO:0008152, metabolic process|GO:0034654, nucleobase-containing compound biosynthetic process|GO:0016070, RNA metabolic process|GO:0044271, cellular nitrogen compound biosynthetic process|GO:0006355, regulation of transcription, DNA-templated|GO:0010557, positive regulation of macromolecule biosynthetic process|GO:0010556, regulation of macromolecule biosynthetic process|GO:0006351, transcription, DNA-templated|GO:0010558, negative regulation of macromolecule biosynthetic process|GO:0032774, RNA biosynthetic process|GO:0044249, cellular biosynthetic process|GO:0034641, cellular nitrogen compound metabolic process|GO:0034645, cellular macromolecule biosynthetic process|GO:0007049, cell cycle|GO:0006139, nucleobase-containing compound metabolic process|GO:1903508, positive regulation of nucleic acid-templated transcription|GO:0009987, cellular process|GO:0006725, cellular aromatic compound metabolic process|GO:1903506, regulation of nucleic acid-templated transcription|GO:1903507, negative regulation of nucleic acid-templated transcription|GO:0045893, positive regulation of transcription, DNA-templated|GO:0090304, nucleic acid metabolic process|GO:0051253, negative regulation of RNA metabolic process|GO:0051252, regulation of RNA metabolic process|GO:0051254, positive regulation of RNA metabolic process|GO:0043170, macromolecule metabolic process|GO:1902680, positive regulation of RNA biosynthetic process|GO:0006807, nitrogen compound metabolic process|GO:0031328, positive regulation of cellular biosynthetic process|GO:0031327, negative regulation of cellular biosynthetic process|GO:0031326, regulation of cellular biosynthetic process|GO:0031325, positive regulation of cellular metabolic process|GO:0031324, negative regulation of cellular metabolic process|GO:0031323, regulation of cellular metabolic process|GO:1903047, mitotic cell cycle process|GO:0044770, cell cycle phase transition|GO:0044772, mitotic cell cycle phase transition|GO:0022402, cell cycle process|GO:2000112, regulation of cellular macromolecule biosynthetic process|GO:0071704, organic substance metabolic process|GO:0010467, gene expression|GO:0006357, regulation of transcription from RNA polymerase II promoter|GO:0010468, regulation of gene expression|GO:0045935, positive regulation of nucleobase-containing compound metabolic process|GO:0000278, mitotic cell cycle|GO:0019219, regulation of nucleobase-containing compound metabolic process|GO:1902679, negative regulation of RNA biosynthetic process|GO:0009058, biosynthetic process|GO:0009059, macromolecule biosynthetic process|GO:0044763, single-organism cellular process|GO:0051171, regulation of nitrogen compound metabolic process|GO:0051172, negative regulation of nitrogen compound metabolic process|GO:0051173, positive regulation of nitrogen compound metabolic process|GO:0044843, cell cycle G1/S phase transition|GO:0044238, primary metabolic process|GO:0044237, cellular metabolic process|GO:0048523, negative regulation of cellular process|GO:0048522, positive regulation of cellular process

GO:0031974, membrane-enclosed lumen|GO:0043229, intracellular organelle|GO:0043227, membrane-bounded organelle|GO:0043226, organelle|GO:0005737, cytoplasm|GO:0016604, nuclear body|GO:0031981, nuclear lumen|GO:0005634, nucleus|GO:0005654, nucleoplasm|GO:0044451, nucleoplasm part|GO:0043231, intracellular membrane-bounded organelle|GO:0043233, organelle lumen|GO:0097504, Gemini of coiled bodies|GO:0044464, cell part|GO:0005623, cell|GO:0005622, intracellular|GO:0044446, intracellular organelle part|GO:0070013, intracellular organelle lumen|GO:0044428, nuclear part|GO:0044424, intracellular part|GO:0015030, Cajal body|GO:0044422, organelle part

GO:0008022, protein C-terminus binding|GO:0000989, transcription factor activity, transcription factor binding|GO:0047485, protein N-terminus binding|GO:0003714, transcription corepressor activity|GO:0003713, transcription coactivator activity|GO:0003712, transcription cofactor activity|GO:0005488, binding|GO:0005515, protein binding|GO:0000988, transcription factor activity, protein binding

 

http://www.uniprot.org/uniprot/G1MEC8

FALSE