Table 5 Differences in binding affinities of TLR7 agonists based on TLR7 functionality.

From: The role of TLR7 agonists in modulating COVID-19 severity in subjects with loss-of-function TLR7 variants

TLR7 agonist

Binding affinity based on functionality

F value

P value

Loss-of-function

Hypofunctional

Neutral

Imiquimod

− 1.47 ± 3.16

− 5.60 ± 3.75

− 7.38 ± 0.48

9.01

0.001

Resiquimod

− 1.76 ± 3.14

− 5.83 ± 3.93

− 5.74 ± 3.21

4.35

0.026

Gardiquimod

− 1.30 ± 2.80

− 5.80 ± 3.90

− 5.54 ± 3.10

5.98

0.008

Vesatolimod

− 2.16 ± 3.86

− 6.15 ± 4.10

− 6.90 ± 3.86

3.74

0.040

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