Figure 1

Schematic illustration of critical steps in developing the representative mPV geometries. (A) Each excised mPV was pressurized to set 0, 10, 20, or 30 mmHg, fixed, then (B) imaged with microCT. (C) A short-axis view from a raw µCT image showing the mPV and the surrounding pulmonary artery. (D) An example of segmented mPV leaflets from µCT images showing the anterior, right and left leaflets. (E) Selected gQOI on a segmented mPV geometry, where β was the tilt angle between the sino-tubular-junction (STJ) and annular (ANL) planes. Q, the upper center, was taken as the average position of the commissure points. (F) Central radial cross section (black) of a segmented leaflet and the estimate demarcation boundary (dark red) between the coaptation and belly regions (FE, BA, CA indicated the free edge, basal attachment and commissure attachment of the leaflet, respectively). (G) The generic geometric model (for a single leaflet shown only) and the associated central cross sections cc, rr along the circumferential and radial directions. (H) Estimate root distention showing displacement of the basal attachment as TVP increased.