Figure 2
Cellular deconvolution of neuronal and non-neuronal subtypes in FCD IIa and IIb using the Schirmer (SR) signature. (A,B) Violin plots of estimated cell type proportions in FCD IIa and IIb lesions of (A) excitatory and inhibitory neurons, and (B) non-neuronal cells. The y-axis indicates the absolute proportion (0 to 1) estimated by CIBERSORTx, while the x-axis indicates the patient dataset. Significant changes between cell type estimates in FCD IIa and IIb lesions were detected using the Wilcoxon rank-sum test. ˙p < 0.1, *p < 0.5, **p < 0.01, ***p < 10−3, ****p < 10−4. EN = excitatory neurons, IN = inhibitory neurons, and PYR = pyramidal neurons. L indicates the cortical layer (e.g. L2/3 refers to layers 2–3), Endo = endothelia, OL = oligodendrocytes, OPC = oligodendrocytes progenitor cells, A/B/C = subclusters A, B, C.
