Table 3 DFPP treatment and TG clearance during the first 48 h after diagnosis in patients according to DTD time tertiles.

From: Initiation time of double-filtration plasma apheresis affects the risk of persistent organ failure in hypertriglyceridaemia-induced acute pancreatitis: a retrospective study

 

All patients (n = 89)

T1: ≤ 12 h (n = 30)

T2:13–22 h (n = 30)

T3: ≥ 23 h (n = 29)

P value

DFPP treatment variables

Frequency of DFPP > 1, n (%)

24 (27)

11 (36.7)

9 (30)

4 (13.8)

0.127

TG clearance rate, median (IQR), %

73.63 (61.12–83.37)

69.14 (43.3–83.3)

75.45 (64.35–83.22)

74.86 (65.12–84.38)

0.276

Volume of plasma processed, median (IQR), L

5 (3–5)

4.3 (3–5)

5 (3–5)

5 (3–5)

0.524

Treatment duration, median (IQR), min

200 (147.5–250)

180 (140–245)

218 (160–280)

200 (164–235)

0.328

Dynamics of TG levels

TG0, median (IQR), mmol/L

58.3 (39.69–80.05)

63.58 (35.84–80.83)

57.41 (44.44–76.75)

54.26 (40.04–81.61)

0.756

TG0 > 56.5 mmol, n (%)

46 (51.7)

16 (53.3)

16 (53.3)

14 (48.3)

0.905

TG24h, median (IQR), mmol/L

8.99(4.67–19.35)

7.22 (3.04–14.77)

5.84 (3.14–9.78)

17.95 (16.58–27.64)

< 0.001

TG24h < 5.65 mmol/L, n (%)

29 (32.6)

15 (50)

13 (43.3)

1 (3.4)

< 0.001

TG48h, median (IQR), mmol/L

4.44 (3.2–6.03)

3.91 (3.19–5.41)

4.27 (3.08–6.26)

5 (3.64–7.31)

0.178

TG48h < 5.65 mmol/L, n (%)

67 (75.3)

24 (80)

23 (76.7)

20 (69)

0.603

24 h-TG clearance rate, median (IQR), %

83.25 (69.53–91.45)

86.15 (80–91.51)

89.61 (83.01–94.44)

52.54 (42.38–73.66)

< 0.001

48 h-TG clearance rate, median (IQR), %

91.81 (87.91–94.02)

91.95 (88.59–94.69)

91.91 (87.96–94.21)

91.4 (86.46–92.81)

0.358

  1. Significant values are in bold.
  2. DFPP double filtration plasmapheresis, DTD from diagnosis to completion of one DFPP session, IQR interquartile range, POF persistent organ failure, TG triglycerides, TG0 the level of triglycerides at presentation, TG24h the level of triglycerides at 24 h after diagnosis, TG48h the level of triglycerides at 48 h after diagnosis, 24 h-TG clearance rate calculated as TG0 − TG24h/TG0; 48 h-TG clearance rate calculated as TG0 − TG48h/TG0.
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