Table 1 Clinical characteristics and sample overview.

From: Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders

 

Total sample

(n = 465)

SZ

N = 291

BD

N = 174

Statistics

Age, mean ± SD

30.48 ± 10.21

29.37 ± 9.13

32.33 ± 11.59

t = 3.06

P = 0.002

Female, N (%)

206 (44.30)

104 (35.70)

102 (58.60)

X2 = 23.11

P < .001

Europeans, N (%)

392 (84.30)

240 (82.50)

152 (87.40)

X2 = 1.96

P = .16

Marital status, married or live-in partner, N (%)

119 (25.60)

57 (19.60)

62 (35.60)

X2 = 14.72

P < .001

Employed or fulltime student, N (%)

149 (32.10)

80 (27.60)

69 (39.70)

X2 = 361.03

P < .001

Daily tobacco users, N (%)

277 (59.57)

179 (62.40)

98 (56.30)

X2 = 1.65

P = .20

Audit score, mean ± SD

7.31 ± 6.71

7.04 ± 6.93

7.78 ± 6.31

t = 73

P = .14

Education, years, mean ± SD

12.56 ± 2.64

12.17 ± 2.72

13.22 ± 2.36

t = .57

P = .28

CTQ, mean ± SD

43.84 ± 15.38

44.25 ± 15.09

43.19 ± 15.83

t = .68

P = .50

Physical abuse, mean ± SD

6.90 ± 3.50

6.93 ± 3.58

6.84 ± 3.36

t = .27

P = .79

Sexual abuse, mean ± SD

6.60 ± 3.52

6.46 ± 3.22

6.84 ± 3.96

t = .38

P = .70

Emotional abuse, mean ± SD

10.56 ± 5.18

10.63 ± 10.44

10.44 ± 5.43

t = .90

P = .37

Physical neglect, mean ± SD

7.81 ± 3.02

7.93 ± 2.94

7.61 ± 3.15

t = 1.10

P = .27

Emotional neglect, mean ± SD

11.92 ± 5.01

12.08 ± 4.96

11.64 ± 5.10

t = -.68

P = .50

ANK3*, mean ± SD

5.49 ± 0.39

5.47 ± 0.39

5.54 ± 0.38

t = 1.90

P = .06

DDD, mean ± SD

1.66 ± 1.81

1.69 ± 2.05

1.61 ± 1.29

t = .49

P = .63

Depressive symptoms#, mean ± SD

.00 ± 1.00

.05 ± 1.00

− .05 ± 1.01

t = 1.08

P = .28

AAO, mean ± SD

22.05 ± 9.04

21.54 ± 8.39

22.85 ± 9.94

t = 1.64

P = .12

AAO Depression, mean ± SD

21.33 ± 8.56

20.70 ± 7.62

21.98 ± 9.39

t = 1.29

P = .20

AAO Mania/hypomania, mean ± SD

24.79 ± 9.57

22.34 ± 5.78

25.70 ± 10.13

t = 2.25

P = .03

AAO psychosis

24.44 ± 8.84

23.55 ± 8.20

26.37 ± 9.86

t = 3.21

P = .0.03

Total episodes, mean ± SD

5.47 ± 5.42

3.48 ± 3.79

8.35 ± 6.10

t = 9.63

P < .001

Depression episodes, mean ± SD

2.85 ± 4.33

1.73 ± 3.25

4.64 ± 5.17

t = 6.51

P < .001

Mania/hypomania episodes,

mean ± SD

1.77 ± 4.03

.42 ± 1.99

4.01 ± 5.36

t = 8.22

P < .001

Psychosis episodes, mean ± SD

1.58 ± 1.96

1.60 ± 1.59

1.53 ± 2.40

t = .39

P = .72

  1. SZ schizophrenia spectrum, BD bipolar disorder, CTQ childhood trauma questionnaire, DDD daily defined dose; * ANK3 mRNA adjusted for age, sex and time of blood sample. #Depressive symptoms were assessed by the z scores of Calgary Depression Scale for Schizophrenia (CDSS) and The Inventory for Depressive Symptomatology (IDS) for bipolar disorder. AAO age at onset, SD standard deviation, Audit alcohol use disorders identification test.
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