Table 2 ANK3 mRNA moderates the association between subtypes of trauma and clinical traits.

From: Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders

 

Number of manic or hypomanic episodes

Age at onset manic or hypomanic episode

ß

t

se

P

CI

ß

t

se

P

CI

CTQ total

 Interaction

.04

1.28

.03

.20

− .02 to − .10

− .04

− .48

.09

.63

−  .21 to − .13

Physical abuse

 

 Interaction

− .06

− .56

.11

.58

− .27 to − .15

− .12

− .29

.41

.77

− .92 to − .68

Sexual abuse

 

 Interaction

.43

2.97

.15

.003

.14 to − .71

− 1.23

− 2.59

.46

.006

− .2.10 to − .36

Conditional effect

 

 High ANK3

.27

3.50

.08

.0005

.12 to − .42

− .64

− 2.56

.25

.01

− 1.14 to − .15

 Intermediate ANK3

.10

1.97

.05

.05

.001 to − .20

− .16

− .91

.17

.36

− .49 to − .18

 Low ANK3

− .07

− .90

.08

.36

− .22 to − .08

.33

1.40

.24

.16

− .13 to − .80

Emotional abuse

 

 Interaction

.09

1.06

.09

.29

− .08 to − .27

.11

.44

.26

.66

.39 to − .62

Physical neglect

 

 Interaction

.04

.23

.18

.81

− .30 to − .38

.27

.53

.50

.60

− .73 to 1.26

Emotional neglect

 

 Interaction

.24

2.52

.09

.0009

.06 to − .42

− .20

− .76

.26

.45

− .70 to − .31

Conditional effect

 

 High ANK3

.21

4.21

.05

 < 0.001

.11 to − .31

 

 Intermediate ANK3

.12

3.38

.04

.0008

.05 to − .19

 Low ANK3

.03

.52

.05

.60

− .07 to − .12

  1. AAO age at onset, CTQ childhood trauma questionnaire. Moderation analyses performed using Process with bootstrapping. Analysis adjusted for the time of the blood sample, diagnosis, sex, age and medication (total defined daily dose). Trauma data are all continuous. mRNA data are continuous. High ANK3 group = 1 SD > mean levels. Intermediate ANK3 group = mean ANK3 levels and Low ANK3 group = 1 SD < mean levels.
  2. To control the Type I error rate we only investigated conditional effects if the interaction analysis was statistical significant.
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