Table 3 ANK3 mRNA moderates the association between subtypes of trauma and clinical traits adjusted for current depressive symptoms.

	Number of manic or hypomanic episodes					Age at onset manic or hypomanic episode
	ß	t	se	P	CI	ß	t	se	P	CI
CTQ total
Interaction	.03	.95	.03	.34	− .03 to − .09	.01	.09	.09	.93	− .17 to − .19
Physical abuse
Interaction	− .07	− .67	.11	.51	− .28 to − .14	− 0.01	− 0.3	.41	.98	− 8.95 to − 4.05
Sexual abuse
Interaction	.39	2.71	.14	.007	.11 to − .67	− 1.28	− 2.86	0.45	.005	− 2.16 to − .40
Conditional effect
High ANK3	.25	3.22	.08	.001	.10 to − .41	− .61	− 2.39	.26	.02	− 1.12 to − .11
Intermediate ANK3	.08	1.58	.05	.12	− .02 to − .19	− .08	− .46	.17	.65	− .42 to − .26
Low ANK3	− .04	− .53	.07	.60	− .18 to − .10	.40	1.70	.24	.09	− .06 to − .87
Emotional abuse
Interaction	.08	.88	.09	.38	− .10 to − .25	.24	.90	.27	.37	− .29 to − .78
Physical neglect
Interaction	− .04	− .24	.17	.81	− .39 to − .30	.59	1.13	.52	.26	− .43 to − 1.61
Emotional neglect
Interaction	.20	2.16	.09	.03	.02 to − .38	− .06	− .21	.27	.83	− .59 to − .47
Conditional effect
High ANK3	.18	3.45	.05	.006	.08 to − .29
Intermediate ANK3	.09	3.53	.04	.12	.02 to − .17
Low ANK3	.03	.67	.05	.54	− .07 to − .13

Process. CTQ childhood trauma questionnaire. Moderation analyses performed using Process with bootstrapping. Adjusted for the time of the blood sample, diagnosis, sex, age and medication (total defined daily dose) and current depressive symptoms. Depressive symptoms were assessed by the z scores of Calgary Depression Scale for Schizophrenia (CDSS) and The Inventory for Depressive Symptomatology (IDS) for bipolar disorder. Trauma data are all continuous. mRNA data are continuous. Data not shown: No significant findings for age at first psychotic or first depressive episode, or number of psychotic or depressive episodes (n.s.).
To control the Type I error rate we only investigated conditional effects if the interaction analysis was statistical significant.

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