Figure 2 | Scientific Reports

Figure 2

From: Metabolites for monitoring symptoms and predicting remission in patients with depression who received electroconvulsive therapy: a pilot study

Figure 2

Correlations between plasma metabolite levels and depressive symptoms during ECT. Longitudinal change in plasma metabolite over three pre-ECT session time points (T1, T3, and T5) and for 3 days after the final ECT session (T7) were assessed (A). PLS-DA score plot showing the gradual change in levels of metabolites during the course of ECT in patients with MDD (B). VIP scores for Fig. 2B were shown in Table S4. The bar chart indicating Pearson’s correlation between the level of each metabolite and the MADRS score, with the amino acids, amino acid derivatives, and oligopeptides were highlighted in red (C). Abbreviations: ECT, electroconvulsive therapy; MDD, major depressive disorder; Gln, glutamine; Leu, leucine; MADRS, Montgomery–Asberg Depression Rating Scale; Ile, isoleucine; PLS-DA, partial least-squares discriminant analysis; βAla-His, beta alanylhistidine; γGlu-Ser, gamma glutamylserine.

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