Table 2 The APZ solubility at distinctive operational conditions (12–30 MPa) and (308–338 K).

From: Experimental solubility of aripiprazole in supercritical carbon dioxide and modeling

Temperature (K)a

Pressure (MPa)a

Density (kg.m−3)b

Y2 × 105 (Mole Fraction)

Standard deviation of the mean, SD(ȳ) × (105)

Expanded uncertainty × 106

S × 10 (Solubility (g.l−1))

308

12

768.42

0.303

0.015

0.306

0.237

15

816.06

0.391

0.026

0.526

0.325

18

848.87

0.467

0.022

0.450

0.404

21

874.4

0.513

0.034

0.688

0.457

24

895.54

0.569

0.050

1.007

0.520

27

913.69

0.634

0.064

1.287

0.591

30

929.68

0.679

0.079

1.586

0.644

318

12

659.73

0.262

0.012

0.246

0.176

15

743.17

0.357

0.023

0.466

0.270

18

790.18

0.471

0.031

0.627

0.379

21

823.7

0.573

0.050

1.007

0.481

24

850.1

0.675

0.079

1.586

0.585

27

872.04

0.741

0.072

1.448

0.659

30

890.92

0.801

0.090

1.807

0.727

328

12

506.85

0.231

0.007

0.148

0.119

15

654.94

0.304

0.021

0.425

0.203

18

724.13

0.496

0.025

0.510

0.366

21

768.74

0.643

0.048

0.969

0.504

24

801.92

0.759

0.073

1.468

0.620

27

828.51

0.847

0.086

1.729

0.716

30

850.83

0.913

0.077

1.551

0.792

338

12

384.17

0.183

0.006

0.126

0.072

15

555.23

0.258

0.017

0.344

0.146

18

651.18

0.499

0.043

0.866

0.331

21

709.69

0.699

0.056

1.129

0.506

24

751.17

0.877

0.078

1.570

0.671

27

783.29

0.958

0.095

1.910

0.764

30

809.58

1.036

0.120

2.409

0.855

  1. The experimental standard deviation of the mean (SD) were obtained by \(SD\left(\overline{y }\right)=\frac{s\left({y}_{k}\right)}{\sqrt{n}}\) . n is the number of times each experimental data was measured (n = 3, in this work). Expanded uncertainty is U = k*ucombined and the relative combined standard uncertainty is defined as ucombined/y =\(\sqrt{\sum_{i=1}^{N}\,{(\mathrm{Pi\,u}(\mathrm{xi})/\mathrm{xi})}^{2}}\) in which u(xi)/xi is the relative standard uncertainty of each input estimate (xi) and Pi is known positive or negative number having negligible uncertainties.
  2. aStandard uncertainty u are u(T) = 0.1 K; u(p) = 1 bar. Also, the relative standard uncertainties are obtained below 0.05 for mole fractions and solubility’s. The value of the coverage factor k = 2 was chosen on the basis of the level of confidence of approximately 95 percent. Data from the Span–Wagner equation of state.