Table 1 Tumour-wise treatment characteristics and outcomes.

From: Novel MRI-guided focussed ultrasound stimulated microbubble radiation enhancement treatment for breast cancer

Tumour number

Site

RT dose

Tumour/replacement fibrosis size at various intervals (mm)

Clinical outcomes

Pre RT

Post RT 1 week

Post RT 1 month

Post RT 3 months

Post RT 1 year

Toxicity (dermatitis)

Follow-up 3 months

Follow-up 12 months

1

Left retroareolar mass

40 Gy/10#

59 × 48 × 27

57 × 42 × 29

48 × 27 × 16

CR

CR

Grade 1

No tumour (complete response)

No tumour (complete response)

2L

Right breast lump with skin involvement

30 Gy/5#

24 × 24 × 16

26 × 21 × 12

24 × 21 × 12

15 × 12 × 15 (RF)

10 × 6 × 9 (RF)

Grade 1

No tumour (replacement fibrosis)

No tumour (replacement fibrosis)

2R

Left breast lump

30 Gy/5#

23 × 23 × 27

21 × 27 × 25

21 × 23 × 24

22 × 18 × 17 (RF)

15 × 12 × 12 (RF)

Grade 1

No tumour (replacement fibrosis)

No tumour (replacement fibrosis)

3

Right chest wall lump

30 Gy/5#

23 × 15 × 13

19 × 22 × 17

17 × 13 × 14

CR

CR

Grade 2

No tumour (complete response)

No tumour (complete response)

4

Right breast lump

30 Gy/10#

53 × 42 × 50

43 × 39 × 25

34 × 28 × 16

11 × 10 × 16 (RF)

CR

Grade 1

No tumour (replacement fibrosis)

No tumour (complete response)

5

Left breast lump

20 Gy/5#

20 × 28 × 38

17 × 20 × 17

16 × 14 × 15

14 × 13 × 14 (RF)

CR

Grade 1

No tumour (replacement fibrosis)

No tumour (complete response)

6

Left retroareolar lump

20 Gy/5#

37 × 27 × 26

36 × 32 × 23

35 × 24 × 27

30 × 26 × 25 (RF)

28 × 20 × 25 (RF)

Grade 1

Increase in left breast inflammatory area for re-irradiation surrounding treated region

No tumour (replacement fibrosis)

7

Left breast skin nodules

40 Gy/10#

62 × 45 × 39

30 × 35 × 31

23 × 24 × 18

CR

NA

Grade 1

No tumour (complete response)

No tumour at 9 months, died of metastatic disease at 9 months

8

Left chest wall lump with skin involvement adherent to chest wall

20 Gy/5#

88 × 65 × 68

63 × 102 × 39

61 × 63 × 28

NA

NA

Grade 1

Died of metastatic disease at 3 months

NA

  1. RT radiotherapy, CR complete response, RF replacement fribrosis.