Figure 8 | Scientific Reports

Figure 8

From: p70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab

Figure 8

Volcano plots of relative expression of genes in the nanoString PanCancer IO 360 panel in GC PDX tumors. X-axes show lower (to the left of 0) or higher (to the right of 0) log2-fold change in expression of genes in all other tumors versus those in Group A (DIACC3010-sensitive; Panel [a]), Group D (combination-sensitive; Panel [b]) or Group E (resistant; Panel [c]). Y-axes show the -log10 unadjusted p value, and horizontal lines denote levels of Benjamini–Yekutieli (BY) corrected adjusted p values. Tables to the right of each plot list those genes differentially expressed by at least 2.0 log2-fold and statistically significant with an adjusted p value of < 0.05. Nine and 2 genes were significantly expressed by Group A models (a) and Group D models (b), respectively, at more than 2-(log2)-fold versus all other models. No genes with significant differential expression were detected in Group E versus all others (c).

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