Figure 2 | Scientific Reports

Figure 2

From: LAMP1 as a novel molecular biomarker to predict the prognosis of the children with autism spectrum disorder using bioinformatics approaches

Figure 2

LAMP1 up-regulation in blood and brain samples of human autism cohorts and animal models. (A)The gene expression levels of LAMP1 in blood samples from ASD patients and healthy controls based on dataset GSE6575 (a), GSE18123 (b), GSE111176 (c) and GSE87847 (d). (B)The gene expression levels of Lamp1 in autistic mouse models. (a) Lamp1 expression in hippocampus tissues from autistic BTBR T+ ltrp3tf/J mice and normal brain tissues based on dataset GSE81501. (b) Lamp1 expression in mouse primary cortical neurons when treated with 1 µM IBET858 for 12 h in Mecp−/− callosal projection neurons according to dataset GSE72149. (c) Lamp1 expression in callosal projection neurons from Mecp2-null mice in dataset GSE50225. (d) Lamp1 expression in the E16 primary cortical neuron cultures after transduction with shRNA constructs of ASD-implicated genes (ACGs): Mecp2, Mef2a, Mef2d, Fmr1, Nlgn1, Nlgn3, Pten, and Shank3 in dataset GSE47150. (C)The gene expression levels of LAMP1 in brain tissues from ASD patients and healthy controls. (a, b) The gene expression levels of LAMP1 in cerebellum and occipital tissues from ASD patients and healthy controls based on dataset GSE38322. (c) The gene expression levels of LAMP1 in postmortem cerebellum tissue from ASD and control groups in dataset GSE28521. The asterisk indicates the level of statistically significance (*P.Value < 0.05 and ***P.Value < 0.01).

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