Figure 5 | Scientific Reports

Figure 5

From: LAMP1 as a novel molecular biomarker to predict the prognosis of the children with autism spectrum disorder using bioinformatics approaches

Figure 5

LAMP1 methylation altered in ASD patients’ blood samples. We investigated the differential methylation levels around the LAMP1 genomic region using GSE109905, a genome-wide DNA methylation profile of ASD (n = 38) and controls (n = 31) utilizing peripheral blood samples based on the platform GPL13534, the Illumina Infinium HumanMethylation450 (450K) BeadChip array. The Beta Mixture Quantile Dilation (BMIQ) approach was used to standardize the beta values. The differentially methylated sites (DMPs) were examined using the limma program. To measure methylation levels, the ratio of intensities between methylated and unmethylated alleles (beta-values) is utilized. Two CpG sites, cg19625388 (P.Value = 7.28e − 03) and cg12557626 (P.Value = 7.81e − 03) with most significant differential methylation levels was shown (A) and (B).

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