Table 2 Comparisons between patients with UC diagnosed in the prebiologic and biologic era.
Prebiologic era | Biologic era | P value | |
|---|---|---|---|
Number of patients | 44 (23.7%) | 142 (76.3%) | |
Gender, male (n [%]) | 33 (75.0%) | 102 (71.8%) | 0.681 |
Age at the time of diagnosis, years, Mean (SD) | 24.3 (10.6) | 31.9 (16.0) | < 0.001 |
Disease duration, years, Mean (SD) | 24.8 (6.0) | 7.4 (4.9) | < 0.001 |
CDAI at diagnosis, Mean (SD) | 72.5 (62.7) | 44.2 (45.5) | 0.003 |
Treatment | |||
Biological treatment | 36 (81.8%) | 110 (77.5%) | 0.539 |
IFX (n [%]) | 30 (68.2%) | 74 (52.1%) | 0.061 |
IFX-BS (n [%]) | 4 (9.1%) | 32 (22.5%) | 0.049 |
ADA (n [%]) | 12 (27.3%) | 45 (31.7%) | 0.579 |
UST (n [%]) | 2 (4.5%) | 14 (9.9%) | 0.272 |
Other treatment | |||
5-ASA (n [%]) | 40 (90.9%) | 111 (78.2%) | 0.059 |
Corticosteroids | 23 (52.2%) | 59 (41.5%) | 0.191 |
Immunomodulator (n [%]) | 17 (38.6%) | 70 (49.3%) | 0.245 |
Apheresis (n [%]) | 2 (4.5%) | 12 (8.5%) | 0.385 |
Probiotics (n [%]) | 28 (64.6%) | 88 (62.0%) | 0.801 |
Elemental diet (n [%]) | 24 (54.5%) | 63 (44.4%) | 0.111 |
Dose of elemental diet, kcal (SD) | 806.3 (389.9) | 660.3 (285.4) | |
Herbal drug (n [%]) | 2 (4.5%) | 10 (7.0%) | 0.579 |
