Table 3 Expression level of p53 and β-Catenin genes in the renal tissue of negative control mice and mice given orally acrylamide or/and TiO2NPs.

From: Estimation of genomic and mitochondrial DNA integrity in the renal tissue of mice administered with acrylamide and titanium dioxide nanoparticles

Group

Treatment (dose mg/kg)

β-Catenin

P53

I

Negative control (deionized water)

1.00 ± 0.00a

1.00 ± 0.00a

II

Acrylamide (3 mg/kg)

0.71 ± 0.06b

2.57 ± 0.09b

III

TiO2-NPs (5mg/kg)

0.81 ± 0.03c

1.70 ± 0.04c

IV

Acrylamide + TiO2-NPs

0.50 ± 0.05d

2.48 ± 0.08d

One way analysis of variance

F = 73.61

P < 0.001

F = 339.81 P < 0.001

  1. Six mice were used for each group.
  2. Results are expressed as mean ± SD.
  3. Results were analyzed using one-way analysis of variance followed by Duncan’s test to test the similarity between the control and three treated groups.
  4. According to Duncan's test means with different letters indicates statistical significant difference between the compared groups in the same column at a significant level of p < 0.001.
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