Figure 4
From: Controlled tumor heterogeneity in a co-culture system by 3D bio-printed tumor-on-chip model
(A) COMSOL simulation of the device with red and blue represent higher and lower concentrations, (B) gradient formation in the 5 min intervals. The migration of MDA-MB-231 (green) and MCF10A (red) toward EGF in the microfluidic chamber; imaged on the higher concentrated of the chamber before and after EGF gradient flow: MDA-MB-231/MCF10A ratio 1:1 (S11) (C), MCF7/MCF10A ratio 1:4 (S14) (D) and MDA-MB-231/MCF10A ratio 4:1 (S41) (E). The respective percentage of MDA-MB-231 cells in before and after EGF exposure are shown for each panel.
