Figure 8
Schematics for the hypothetical mechanism of TRIM26-mediated HBc deubiquitination. HBc is prevented from ubiquitination and proteasome-dependent degradation in the presence of TRIM26, while HBc is subjected to polyubiquitination and proteasome-dependent degradation in the absence of TRIM26. Three hypothetical mechanistic models can be considered for the TRIM26-mediated inhibition of the proteasome-dependent HBc degradation. i) TRIM26 sequestrates an unknown E3 ubiquitin ligase from HBc by competitive binding. ii) TRIM26 ubiquitinates an unknown HBc-specific deubiquitinase to activate the catalysis. iii) TRIM26 inactivates the catalysis of an unknown HBc-specific E3 ubiquitin ligase.
