Figure 4 | Scientific Reports

Figure 4

From: Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway

Figure 4

The expression and secretion of pro-inflammatory cytokines after ICH are repressed by P2X4 knockdown. (A) The tissue mRNA levels of IL-1β, IL-6, and TNF-α were determined with qRT-PCR. (B–D) The serum levels of IL-1β (B), IL-6 (C), and TNF-α (D) were detected with ELISA. One-Way ANOVA and Tukey’s multiple comparisons test was used. N = 6. ** P < 0.01 versus Sham, ## P < 0.01 versus AAV-NC.

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