Figure 1 | Scientific Reports

Figure 1

From: PDI augments kainic acid-induced seizure activity and neuronal death by inhibiting PP2A-GluA2-PICK1-mediated AMPA receptor internalization in the mouse hippocampus

Figure 1

Effects of PDI knockdown on GluA1 phosphorylation in the hippocampus under physiological condition. As compared to control siRNA, PDI siRNA enhances GluA1 S831, but not S845, phosphorylation in the mouse hippocampus. (a) Representative Western blot images for PDI, GluA1, p-GluA1 S831 and p-GluA1 S845 levels. (b–e) Quantitative analyses of the effects of PDI siRNA on PDI (b), GluA1 (c), p-GluA1 S831 (d) and p-GluA1 S845 levels (e) based on the Western blot data (*p < 0.05 vs. control siRNA; n = 7, respectively; Mann–Whitney test).

Back to article page