Table 1 Laboratory parameters.

From: Expression of TNFR1, VEGFA, CD147 and MCT1 as early biomarkers of diabetes complications and the impact of aging on this profile

Parameters

CSA

DMA

*p

CSE

DME

*p

Glycemia (mg/dl)

132.4 ± 45

n = 5

462.7 ± 98.0 n = n = 9

0.001*

106.8 ± 9.2

n = 9

447.4 ± 125.7

n = 7

0.0002*

HbA1c (%)

4.5 ± 0.2

n = 5

9.0 ± 2.0

n = 8

0.0016*

4.6 ± 0.05

n = 5

9.3 ± 1.3

n = 4

0.008*

Ureia (mg/dL)

48.5 ± 6.9

n = 5

135.5 ± 38.3

n = 6

0.0043*

45.4 ± 9.1

n = 9

93.2 ± 53.8

n = 7

0.023*

Plasma crea. (mg/dL)

0.6 ± 0.1

n = 5

0.7 ± 0.1

n = 6

0.0065*

0.5 ± 0.1 n = 9

0.7 ± 0.1

n = 7

0.01*

Urine crea. (mg/dL)

60.7 ± 11.2 n = 5

21.7 ± 10.3 n = 9

0.001*

63.2 ± 40.8 n = 9

26.4 ± 14.5 n = 6

0.0360*

Creatinine clearance

0.3 ± 0.2

n = 5

0.2 ± 0

n = 4

0.1

0.6 ± 0.2

n = 5

0.3 ± 0.1

n = 4

0.0317*

Proteinuria (mg/dl)

16 ± 3.1

n = 5

12.5 ± 2.3

n = 9

0.0460*

28.3 ± 15.7

n = 9

19.5 ± 11.4

n = 6

0.11

Microalbum (mg/24)a

0.2 ± 0.4

n = 4

0.9 ± 1.8

n = 9

 > 0.9999

2 ± 4.5

n = 9

10.3 ± 20.4

n = 6

0.95

Apo B/A ratio

1.2 ± 0.7

n = 5

0.8 ± 0.2

n = 6

0.6623

0.8 ± 0.3

n = 9

0.4 ± 0.2

n = 6

0.1

Cystatin C (mg/L)

0.2 ± 0.01

n = 5

0.2 ± 0.1

n = 4

 > 0.9999

0.17 ± 0.01

n = 6

0.2 ± 0.1

n = 4

0.14

  1. aMost microalbuminuria values were zero. Values presented as mean ± DSVP and number of samples. Mann–Whitney and Student’s t-test *P < 0.05. 95% CI. Reference values for Wistar rats: Glycemia: 72–193 mg/dL; HbA1c: 4–6%; Urea: 45–80 mg/dL; Plasma Crea.: 0.24–1.20 mg/dL; Urine Crea.: 32–97.4 mg/dL; Creatinine clearance: 0.2–1.8 mL/min; Proteinuria: 8.8–33.2 mg/dL; Microalbuminuria: < 20 mg/24; Apo B/A Ratio: 0.7–1.2; Cystatin C: 0.18–1.5 mg/dL30,31,32,33,34,35.
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