Figure 8 | Scientific Reports

Figure 8

From: Ocular steroidome in human eyes and in eyes with complex central serous chorioretinopathy (CSCR)

Figure 8

Multimodal imaging of a 32-year-old woman with bilateral chronic CSCR. (A) Intermediate phase at 4 min shows mild staining in the inferior foveal zone and moderate stippled hyperfluorescence at the level of the superior arcade on fluorescein angiography of the right eye, corresponding to a hyperfluorescent plaque on indocyanine green angiography (ICGA). The intermediate cliché at 7 min of the left eye, (B) shows a mild FA staining surrounding the foveal SRF pocket, corresponding to granular stippled hyperfluorescence on ICGA (C–G). spectral-domain optical coherence tomography (SD-OCT) of the left and right eye during follow-up, respectively (C). The exam recorded in 2018 already showed a foveal neurosensory dome-shaped detachment with photoreceptor elongation and thickened choroid (D–F). Progressive SRF resolution after starting systemic mineralocorticoid antagonist therapy. The effect of the treatment on choroidal thickness cannot be evaluated without the enhanced depth imaging focus (EDI) (G). Additional topical dexamethasone treatment increased SRF reduction. Note the vascular enlargement with choriocapillary attenuation and signal hypertransmission underneath the residual neurosensory detachment and slight RPE elevation. No macular neovascularization was observed at that timepoint in both eyes (OCTA not shown).

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