Table 1 Descriptive statistics of NHW and MA participants categorized by population and cognitive phenotype in the Texas Alzheimer’s Research and Care Consortium for buffy coat mitochondrial DNA oxidative mutational load.

From: Integrative blood-based characterization of oxidative mitochondrial DNA damage variants implicates Mexican American’s metabolic risk for developing Alzheimer’s disease

	NC	MCI	AD	P-value^a
Total Number of Subjects	328	127	104
Non-Hispanic Whites	153	43	64
Age [CI]	70.39 ± 1.178	71.35 ± 1.421	71.70 ± 1.056	0.338
Sex (F) [n, %]	78, 50.98%	21, 48.84%	29, 45.31%	0.747
Mini Mental State Exam (MMSE) [CI]	29.11 ± 0.1759	27.63 ± 0.6223	21.53 ± 1.413	< 0.001^b
Clinical Dementia Rating (CDR) Sum [CI]	0.007 ± 0.009	1.163 ± 0.2181	5.344 ± 0.8515	< 0.001^c
Years of Education [CI]	16.07 ± 0.4063	14.56 ± 0.6597	15.11 ± 0.7524	0.001^d
BMI kg/m² [CI]	27.331 ± 1.150	27.272 ± 2.328	27.394 ± 1.062	0.996
Diabetes (Y) [n, %]	59, 38.56%	18, 41.86%	22, 34.38%	0.723
Hypercholesterolemia (Y) [n, %]	90, 58.82%	26, 60.47%	50, 78.13%	0.023
Hyperlipidemia (Y) [n, %]	56, 36.60%	15, 34.88%	39, 60.94%	0.002
Hypertension (Y) [n, %]	100, 65.36%	31, 72.09%	44, 68.75%	0.680
Obesity (Y) [n, %]	27, 17.65%	8, 18.69%	10, 15.63%	0.910
Depression (Y) [n, %]	12, 7.84%	6, 13.95%	17, 26.56%	0.001
Tobacco Abuse (Y) [n, %]	51, 33.33%	18, 41.86%	28, 43.75%	0.279
Alcohol Abuse (Y) [n, %]	3, 1.96%	5, 11.63%	3, 4.69%	0.020
Mexican Americans	175	84	40
Age [CI]	67.62 ± 0.8156	69.88 ± 1.691	73.37 ± 2.485	< 0.001^e
Sex (F) [n, %]	99, 56.57%	40, 47.62%	24, 60.00%	0.302
Mini Mental State Exam (MMSE) [CI]	28.14 ± 0.2889	24.93 ± 1.140	19.87 ± 1.860	< 0.001^f
Clinical Dementia Rating (CDR) Sum [CI]	0.006 ± 7.897₁₀^–3	1.113 ± 0.2261	5.737 ± 1.183	< 0.001^g
Years of Education [CI]	11.05 ± 0.6598	8.77 ± 1.664	9.75 ± 1.547	0.002^h
BMI kg/m² [CI]	30.917 ± 0.9992	31.295 ± 2.228	28.717 ± 1.651	0.116
Diabetes (Y) [n, %]	79, 45.14%	32, 38.10%	19, 47.50%	0.484
Hypercholesterolemia (Y) [n, %]	103, 58.86%	52, 61.90%	23, 57.50%	0.862
Hyperlipidemia (Y) [n, %]	89, 50.86%	35, 41.67%	12, 30.00%	0.120
Hypertension (Y) [n, %]	120, 68.57%	63, 75.00%	28, 70.00%	0.567
Obesity (Y) [n, %]	84, 48.00%	38, 45.24%	8, 20.00%	0.005
Depression (Y) [n, %]	19, 10.86%	29, 34.52%	15, 37.50%	< 0.001
Tobacco Abuse (Y) [n, %]	82, 46.86%	39, 46.43%	18, 45.00%	0.978
Alcohol Abuse (Y) [n, %]	6, 3.43%	0, 0.00%	2, 5.00%	0.172

NC normal control, MCI mild cognitive impairment, AD Alzheimer’s Disease.
^aThe mean difference is significant at 0.05.
^bNC vs. MCI 0.016, NC vs. AD < 0.001, MCI vs. AD < 0.001.
^cNC vs. MCI <0.001, NC vs. AD < 0.001, MCI vs. AD < 0.001.
^dNC vs. MCI 0.003, NC vs. AD 0.042, MCI vs. AD 0.542.
^eNC vs. MCI 0.028, NC vs. AD < 0.001, MCI vs. AD 0.017.
^fNC vs. MCI <0.001, NC vs. AD < 0.001, MCI vs. AD < 0.001.
^gNC vs. MCI <0.001, NC vs. AD < 0.001, MCI vs. AD < 0.001.
^hNC vs. MCI 0.001, NC vs. AD 0.273, MCI vs. AD 0.540.

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Table 1 Descriptive statistics of NHW and MA participants categorized by population and cognitive phenotype in the Texas Alzheimer’s Research and Care Consortium for buffy coat mitochondrial DNA oxidative mutational load.

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