Figure 4 | Scientific Reports

Figure 4

From: Early transcriptomic host response signatures in the serum of dengue patients provides insights into clinical pathogenesis and disease severity

Figure 4

Differential gene expression across the two different viral load groups and functional interpretation of the host transcriptome profile. (a) Volcano plot representing differentially expressed genes highlighting the genes with log fold change of ± 1 and FDR < 0.05, generated using ggplot2 R package. (b) Heatmap of the 25 significant DEGs on log2 scale of normalised counts per million, created using a web tool, SR Plot (https://www.bioinformatics.com.cn/). (c) An overview of the possible mechanism of early host response, shifting the course of dengue infection towards mild or severe disease. Blue arrows indicate upregulated genes and red arrow indicates downregulated gene in the HVR group. Figure created with licensed version of BioRender (https://www.biorender.com/).

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