Figure 5
From: Interactions of the male contraceptive target EPPIN with semenogelin-1 and small organic ligands
Interaction model of the full-length EPPIN model with the plasma membrane. The complex EPPIN/SEMG1 peptide was selected for anchoring in a 100% POPC bilayer. EPPIN WFDC domain (blue), Kunitz domain (green) and hinge segment (brown), SEMG1-E2Q peptide (purple), and POPC (yellow) are shown. (a) The initial orientation of the complex was predicted by the OPM server28, with (b) its final orientation obtained after 100 ns of MD simulation. (c) Hydrophobic and (d) polar residues of EPPIN were identified as important in the interaction and anchoring on the plasma membrane.
